CLSI 方法开发和标准化工作组评价抗菌药物敏感性试验的最佳实践。
CLSI Methods Development and Standardization Working Group Best Practices for Evaluation of Antimicrobial Susceptibility Tests.
机构信息
Accelerate Diagnostics, Tucson, Arizona, USA
Wockhardt, Morton Grove Pharmaceuticals, Morton Grove, Illinois, USA.
出版信息
J Clin Microbiol. 2018 Mar 26;56(4). doi: 10.1128/JCM.01934-17. Print 2018 Apr.
Abstract
Effective evaluations of antimicrobial susceptibility tests (ASTs) require robust study design. The Clinical and Laboratory Standards Institute (CLSI) Subcommittee on Antimicrobial Susceptibility Testing has recognized that many published studies reporting the performance of commercial ASTs (cASTs) suffer from major design and/or analysis flaws, rendering the results difficult or impossible to interpret. This minireview outlines the current consensus of the Methods Development and Standardization Working Group of the CLSI Subcommittee on Antimicrobial Susceptibility Testing regarding best practices for systematic evaluation of the performance of an AST, including the analysis and presentation of essential data intended for publication.
摘要
有效的抗菌药物敏感性测试（AST）评估需要稳健的研究设计。临床和实验室标准协会（CLSI）抗菌药物敏感性测试分委员会认识到，许多发表的报告商业 AST（cAST）性能的研究存在主要的设计和/或分析缺陷，使得结果难以或不可能解释。本综述概述了 CLSI 抗菌药物敏感性测试分委员会方法开发和标准化工作组目前关于系统评估 AST 性能的最佳实践的共识，包括用于发表的基本数据的分析和呈现。
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