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9c11tCLA 以不同方式调节人脐静脉内皮细胞中 11t18:1 和 9t18:1 诱导的炎症反应。

9c11tCLA modulates 11t18:1 and 9t18:1 induced inflammations differently in human umbilical vein endothelial cells.

机构信息

State Key Lab of Food Science and Technology, Nanchang University, Nanchang, 330047, China.

Institute for Advanced Study, Nanchang University, Nanchang, 330031, China.

出版信息

Sci Rep. 2018 Jan 24;8(1):1535. doi: 10.1038/s41598-018-19729-9.

DOI:10.1038/s41598-018-19729-9
PMID:29367652
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5784167/
Abstract

Endothelial inflammation is recognized as the initial stage of a multistep process leading to coronary heart disease (CHD). Recently, the different effects of industrial trans fatty acids (elaidic acid, 9t18:1) and ruminant trans fatty acids (vaccenic acid, 11t18:1) on CHD have been reported in epidemiological and animal studies, however, the mechanism was not fully studied. Therefore, the objective of this study was to explore the underlying mechanism by which 9t18:1 and 11t18:1 affect human umbilical vein endothelial cells (HUVECs) inflammation. We found that 9c11t-CLA modulated the inflammation of HUVECs induced by 9t18:1 and 11t18:1. Fatty acid composition, pro-inflammatory factors, phosphorylation of MAPKs, and the TLR4 level in HUVECs altered by 11t18:1 induction, collectively suggest that the bio-conversion of 11t18:1 to 9c11tCLA might be the cause why 11t18:1 and 9t18:1 have distinct influences on endothelial injuries. It was concluded that it is biosynthesis of 9c11t CLA from11t18:1, and the modulation of TLR4-MAPK pathway by 9c11t CLA, which at least partially account for the slight effect of 11t18:1 on endothelial inflammation.

摘要

内皮炎症被认为是导致冠心病 (CHD) 的多步骤过程的初始阶段。最近，流行病学和动物研究报道了工业反式脂肪酸（油酸，9t18:1）和反刍动物反式脂肪酸（蓖麻酸，11t18:1）对 CHD 的不同影响，但机制尚未完全研究。因此，本研究旨在探讨 9t18:1 和 11t18:1 影响人脐静脉内皮细胞 (HUVEC) 炎症的潜在机制。我们发现 9c11t-CLA 调节了 9t18:1 和 11t18:1 诱导的 HUVEC 炎症。11t18:1 诱导的脂肪酸组成、促炎因子、MAPKs 的磷酸化和 TLR4 水平的改变表明，11t18:1 向 9c11tCLA 的生物转化可能是 11t18:1 和 9t18:1 对内皮损伤有不同影响的原因。结论是，11t18:1 生物合成 9c11t CLA，以及 9c11t CLA 对 TLR4-MAPK 通路的调节，至少部分解释了 11t18:1 对内皮炎症的轻微影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7191/5784167/a2c223e0de00/41598_2018_19729_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7191/5784167/b95d361d09ae/41598_2018_19729_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7191/5784167/a4f0e7a5b961/41598_2018_19729_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7191/5784167/627d35fa2858/41598_2018_19729_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7191/5784167/1da4ebd39d8c/41598_2018_19729_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7191/5784167/baca5471f29d/41598_2018_19729_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7191/5784167/a2c223e0de00/41598_2018_19729_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7191/5784167/b95d361d09ae/41598_2018_19729_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7191/5784167/a4f0e7a5b961/41598_2018_19729_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7191/5784167/627d35fa2858/41598_2018_19729_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7191/5784167/1da4ebd39d8c/41598_2018_19729_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7191/5784167/baca5471f29d/41598_2018_19729_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7191/5784167/a2c223e0de00/41598_2018_19729_Fig6_HTML.jpg

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