Ho M, Webster H K, Looareesuwan S, Supanaranond W, Phillips R E, Chanthavanich P, Warrell D A
J Infect Dis. 1986 Apr;153(4):763-71. doi: 10.1093/infdis/153.4.763.
Proliferative responses of T lymphocytes to antigens specific and not specific for malaria were investigated in 32 adult patients in eastern Thailand during acute infection with Plasmodium falciparum malaria and during their convalescence. Immune unresponsiveness to malarial antigen, which persisted for more than four weeks in 37.5% of the individuals, was present in all patients, irrespective of parasitemia or severity of clinical illness. Suppression of responses to nonspecific antigens was less profound and observed only in patients with moderately severe or cerebral malaria. The depressed functional responses were associated with a loss of T lymphocytes--both helper and suppressor subsets--from the peripheral blood; these responses were recovered once parasites were cleared. These results indicate that blood-stage plasmodial infections may suppress responses important for immunity to malaria and so allow the parasite to survive. They further suggest that patients acutely or even recently infected with P. falciparum may not respond as well to a malaria vaccine as would uninfected individuals.
在泰国东部的32名成年患者中，研究了他们在感染恶性疟原虫疟疾急性期和恢复期时，T淋巴细胞对疟疾特异性抗原和非特异性抗原的增殖反应。所有患者均存在对疟疾抗原的免疫无反应性，无论其寄生虫血症或临床疾病严重程度如何，37.5%的个体这种无反应性持续超过四周。对非特异性抗原反应的抑制作用较弱，仅在中度严重或脑型疟疾患者中观察到。功能反应的降低与外周血中T淋巴细胞（辅助性和抑制性亚群）的减少有关；一旦寄生虫被清除，这些反应就会恢复。这些结果表明，血期疟原虫感染可能会抑制对疟疾免疫重要的反应，从而使寄生虫得以存活。它们还进一步表明，急性感染甚至近期感染恶性疟原虫的患者对疟疾疫苗的反应可能不如未感染个体。
