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HIV 阳性男男性行为者中的性化药物使用(“嗑药性行为”)和高危性行为。

Sexualized drug use ('chemsex') and high-risk sexual behaviours in HIV-positive men who have sex with men.

机构信息

Department of Infectious Disease Epidemiology, Imperial College London, London, UK.

HIV and STI Surveillance Department, Public Health England, London, UK.

出版信息

HIV Med. 2018 Apr;19(4):261-270. doi: 10.1111/hiv.12574. Epub 2018 Jan 24.

DOI:10.1111/hiv.12574
PMID:29368440
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5900961/
Abstract

OBJECTIVES

The incidence of sexually transmitted infections (STIs) and HIV infection remains high in gay, bisexual, and other men who have sex with men (MSM) in the UK, and sexualized drug use ("chemsex") and injecting drug use ("slamsex") may play a part in this. We aimed to characterize HIV-positive MSM engaging in chemsex/slamsex and to assess the associations with self-reported STI diagnoses and sexual behaviours.

METHODS

Data from a 2014 survey of people attending HIV clinics in England and Wales were linked to clinical data from national HIV surveillance records and weighted to be nationally representative. Multivariable logistic regression assessed the associations of chemsex and slamsex with self-reported unprotected anal intercourse (UAI), serodiscordant UAI (sdUAI) (i.e. UAI with an HIV-negative or unknown HIV status partner), sdUAI with a detectable viral load (>50 HIV-1 RNA copies/mL), hepatitis C, and bacterial STIs.

RESULTS

In the previous year, 29.5% of 392 sexually active participants engaged in chemsex, and 10.1% in slamsex. Chemsex was significantly associated with increased odds of UAI [adjusted odds ratio (AOR) 5.73; P < 0.001], sdUAI (AOR 2.34; P < 0.05), sdUAI with a detectable viral load (AOR 3.86; P < 0.01), hepatitis C (AOR 6.58; P < 0.01), and bacterial STI diagnosis (AOR 2.65; P < 0.01). Slamsex was associated with increased odds of UAI (AOR 6.11; P < 0.05), hepatitis C (AOR 9.39; P < 0.001), and bacterial STI diagnosis (AOR 6.11; P < 0.001).

CONCLUSIONS

Three in ten sexually active HIV-positive MSM engaged in chemsex in the past year, which was positively associated with self-reported depression/anxiety, smoking, nonsexual drug use, risky sexual behaviours, STIs, and hepatitis C. Chemsex may therefore play a role in the ongoing HIV and STI epidemics in the UK.

摘要

目的

在英国,男同性恋、双性恋和其他与男性发生性关系的男性(MSM)中的性传播感染(STI)和艾滋病毒感染的发病率仍然很高,性化药物使用(“化学性行为”)和注射毒品使用(“ slamsex”)可能在此中起一定作用。我们旨在描述从事化学性行为/ slamsex 的艾滋病毒阳性 MSM,并评估其与自我报告的性传播感染诊断和性行为之间的关联。

方法

对参加英格兰和威尔士艾滋病毒诊所的 2014 年调查的数据与全国艾滋病毒监测记录中的临床数据进行了关联,并进行了加权处理以使其具有全国代表性。多变量逻辑回归评估了化学性行为和 slamsex 与自我报告的无保护肛交(UAI),血清不一致的 UAI(即与 HIV 阴性或未知 HIV 状态的伴侣进行 UAI),与可检测病毒载量相关的血清不一致的 UAI(sdUAI)(> 50 HIV-1 RNA 拷贝/ mL),丙型肝炎和细菌性 STI 的关联。

结果

在过去的一年中,有 29.5%的 392 名活跃的参与者进行了化学性行为,有 10.1%的参与者进行了 slamsex。化学性行为与 UAI 的可能性增加显着相关[校正优势比(AOR)5.73; P <0.001],血清不一致的 UAI(AOR 2.34; P <0.05),血清不一致的 UAI 与可检测病毒载量(AOR 3.86; P <0.01),丙型肝炎(AOR 6.58; P <0.01)和细菌性 STI 诊断(AOR 2.65; P <0.01)。 Slamsex 与 UAI 的可能性增加有关(AOR 6.11; P <0.05),丙型肝炎(AOR 9.39; P <0.001)和细菌性 STI 诊断(AOR 6.11; P <0.001)。

结论

在过去的一年中,有十分之三的活跃的 HIV 阳性 MSM 进行了化学性行为,这与自我报告的抑郁/焦虑,吸烟,非性药物使用,危险性行为,性传播感染和丙型肝炎有关。因此,化学性行为可能在英国的艾滋病毒和性传播感染流行中发挥作用。

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