级联一锅法通过 Pd 催化的 C-H 活化合成异喹啉-1(2H)-酮与α-溴代酮和苯甲酰胺
Cascade One-Pot Method To Synthesize Isoquinolin-1(2H)-ones with α-Bromo Ketones and Benzamides via Pd-catalyzed C-H Activation.
机构信息
School of Chemistry and Chemical Engineering, Shandong University , Jinan 250100, People's Republic of China.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050, People's Republic of China.
出版信息
J Org Chem. 2018 Feb 16;83(4):2317-2323. doi: 10.1021/acs.joc.7b03224. Epub 2018 Feb 5.
A cross-coupling strategy of palladium-catalyzed ortho-C-H bond activation and intramolecular addition of N-C annulation to synthesize isoquinolin-1(2H)-ones has been developed. A wide range of α-bromo ketones with different substituents proceeded smoothly in this reaction, and varieties of isoquinolin-1(2H)-one derivatives were obtained in moderate to good yields.
钯催化的邻位 C-H 键活化与 N-C 环加成的交叉偶联策略已被开发用于合成异喹啉-1(2H)-酮。该反应中，具有不同取代基的各种α-溴代酮都能顺利进行，得到了中等至良好收率的多种异喹啉-1(2H)-酮衍生物。
Zotero 插件