通过一锅不对称铑/钯接力催化反应实现手性二芳基苯并呋喃-3(2H)-酮的对映选择性合成。
Enantioselective Synthesis of gem-Diaryl Benzofuran-3(2H)-ones via One-Pot Asymmetric Rhodium/Palladium Relay Catalysis.
机构信息
Department of Chemistry, Innovative Drug Research Center, Shanghai University , Shanghai 200444, China.
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zuchongzhi Road, Shanghai 201203, China.
出版信息
Org Lett. 2017 May 19;19(10):2726-2729. doi: 10.1021/acs.orglett.7b01070. Epub 2017 May 9.
An asymmetric dual-metal relay catalysis strategy that combines Rh/chiral sulfur-olefin-catalyzed enantioselective 1,2-addition with a Pd-catalyzed intramolecular C-O coupling has been developed. The method allows rapid and efficient synthesis of quaternary carbon-containing gem-diaryl benzofuran-3(2H)-ones in good yields in a highly enantioselective manner (up to 99% ee) through a simple one-pot cascade reaction.
发展了一种不对称双金属继电器催化策略，将 Rh/手性硫-烯烃催化的对映选择性 1,2-加成与 Pd 催化的分子内 C-O 偶联结合在一起。该方法通过简单的一锅级联反应，以高对映选择性（高达 99%ee），快速高效地合成了含有季碳原子的偕二芳基苯并呋喃-3(2H)-酮，产率良好。
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