Research Center of Green Pharmaceutical Technology and Process, Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University , Yichang 443002, China.
Yichang Humanwell Pharmaceutical Co., Ltd., Yichang, 443005, China.
Org Lett. 2018 Feb 16;20(4):1110-1113. doi: 10.1021/acs.orglett.8b00034. Epub 2018 Jan 25.
A novel full atom-economic process for the transformation of alkynes into chiral alcohols by TfOH-catalyzed hydration coupled with Ru-catalyzed tandem asymmetric hydrogenation in TFE under simple conditions has been developed. A range of chiral alcohols was obtained with broad functional group tolerance, good yields, and excellent stereoselectivities.
已开发出一种新颖的全原子经济过程，即在简单条件下，通过 TfOH 催化的水合作用与 Ru 催化的串联不对称氢化反应将炔烃转化为手性醇。通过该过程可以获得一系列具有广泛官能团容忍度、良好收率和优异对映选择性的手性醇。
