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去骨瓣减压术后的长期预后:一个令人尴尬的事实?

Long-term outcome following decompressive craniectomy: an inconvenient truth?

机构信息

Department of Neurosurgery, Sir Charles Gairdner Hospital and Royal Perth Hospital.

Department of Intensive Care Medicine, Royal Perth Hospital and School of Population Health, University of Western Australia, Western Australia, Australia.

出版信息

Curr Opin Crit Care. 2018 Apr;24(2):97-104. doi: 10.1097/MCC.0000000000000481.

Abstract

PURPOSE OF REVIEW

There is little doubt that decompressive craniectomy can reduce mortality following malignant middle cerebral infarction or severe traumatic brain injury. However, the concern has always been that the reduction in mortality comes at the cost of an increase in the number of survivors with severe neurological disability.

RECENT FINDINGS

There has been a number of large multicentre randomized trials investigating surgical efficacy of the procedure. These trials have clearly demonstrated a survival benefit in those patients randomized to surgical decompression. However, it is only possible to demonstrate an improvement in outcome if the definition of favourable is changed such that it includes patients with either a modified Rankin score of 4 or upper severe disability. Without this recategorization, the results of these trials have confirmed the 'Inconvenient truth' that surgery reduces mortality at the expense of survival with severe disability.

SUMMARY

Given these results, the time may have come for a nuanced examination of the value society places on an individual life, and the acceptability or otherwise of performing a procedure that converts death into survival with severe disability.

摘要

目的综述

去骨瓣减压术能降低恶性大脑中动脉梗死或严重颅脑损伤患者的死亡率,这一点几乎毋庸置疑。但人们一直担心的是,死亡率的降低是以增加大量严重神经功能障碍幸存者为代价的。

最新发现

已有多项大型多中心随机试验研究了该手术的疗效。这些试验清楚地表明,接受手术减压的患者有生存获益。然而,如果将预后的定义改为包括改良 Rankin 评分 4 分或更严重残疾的患者,才有可能证明预后有所改善。如果不进行这种重新分类,这些试验的结果证实了“不方便的事实”,即手术降低了死亡率,但代价是存活者有严重残疾。

总结

鉴于这些结果,现在可能需要对社会对个人生命的价值进行细致的审查,以及对实施一种将死亡转化为严重残疾生存的手术的可接受性进行审查。

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