Neonatal Intensive Care Unit, Zeynep Kamil Maternity and Children's Training and Research Hospital, Istanbul, TR.
Neonatal Intensive Care Unit, Medeniyet University, Istanbul, TR.
Retina. 2019 Apr;39(4):706-711. doi: 10.1097/IAE.0000000000002028.
To study the association between thrombocytopenia and retinopathy of prematurity (ROP).
The case-control study was conducted on preterm newborns with ROP between January 2011 and January 2014, retrospectively. The patients were assigned into two groups: Cases required intervention and controls developed no or Stage I ROP.
Eighty-one premature infants with Type I ROP were enrolled to the study with a mean gestational age of 27.6 ± 2.1 (range: 24-32) weeks and birth weight of 993 ± 292 (range: 560-1,930) g. Mean follow-up time was 38.3 ± 2.7 weeks (min: 32 and max: 46 weeks). Cases were individually matched to a set of controls (1:1 ratio). Thrombocytopenia (<150.000/mm) was seen in 58 (71.6%) of the cases with Type I ROP, whereas only 17 (21%) of the controls had thrombocytopenia (P < 0.001). Logistic regression analysis showed that bronchopulmonary dysplasia and thrombocytopenia were significantly associated with Type I ROP (relative risk [95% confidence interval]: 4.19 [1.47-12] and 6.69 [2.83-15.9], respectively). The thrombocytopenia ratio (P = 0.073), thrombocytopenia 1 week before intervention (P = 0.076) and platelet transfusion ratio (P = 0.062) tended to be higher in Zone I ROP compared with Zone II ROP.
In our study, there was a significant association between thrombocytopenia and Type I ROP.
研究血小板减少症与早产儿视网膜病变（ROP）的关系。
采用回顾性病例对照研究，选取 2011 年 1 月至 2014 年 1 月间收治的患有 ROP 的早产儿，将其分为两组：病例组需要干预治疗，对照组为无或 I 期 ROP。
共纳入 81 例 I 型 ROP 早产儿，平均胎龄为 27.6±2.1（范围：24-32）周，出生体重为 993±292（范围：560-1930）g。平均随访时间为 38.3±2.7 周（最短 32 周，最长 46 周）。每个病例组患儿均与一组对照组患儿（1:1 比例）进行配对。在 I 型 ROP 患儿中，58 例（71.6%）存在血小板减少症（血小板计数<150.000/mm），而对照组中只有 17 例（21%）存在血小板减少症（P<0.001）。Logistic 回归分析显示，支气管肺发育不良和血小板减少症与 I 型 ROP 显著相关（相对危险度[95%置信区间]：4.19[1.47-12]和 6.69[2.83-15.9]）。与 II 区 ROP 相比，I 区 ROP 血小板减少症比例（P=0.073）、干预前 1 周血小板减少症（P=0.076）和血小板输注比例（P=0.062）较高。
在本研究中，血小板减少症与 I 型 ROP 之间存在显著关联。
