Department of Ophthalmology and Visual Science, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia.
Hospital Universiti Sains Malaysia, Jalan Raja Perempuan Zainab 2, Kota Bharu Kelantan 16150, Malaysia.
Int J Environ Res Public Health. 2021 Apr 5;18(7):3783. doi: 10.3390/ijerph18073783.
Platelets are a primary source of pro- and anti-angiogenic cytokines. However, the evidence of their role in retinopathy of prematurity (ROP) is controversial. This retrospective study aimed to compare mean weekly platelet counts between infants with and without ROP over the first 6 weeks of life. A total of 93 infants matched by gestational age and birth weight were recruited (31 with ROP, 62 without ROP). Weekly mean platelet counts and other related risk factors were documented. The repeated measure analysis of variance (ANOVA) and the repeated measure analysis of covariance (ANCOVA) were used to compare mean platelet counts over time between the two groups, with and without adjusting for confounders. We found significant differences in the weekly mean platelet counts of infants with and without ROP over the first 6 weeks of life ( = 0.002). These differences disappeared after adjusting for covariates ( = 0.489). Lower mean platelet counts in ROP infants are not directly related to ROP, but rather to the presence of other risk factors for ROP, such as culture-proven sepsis, blood transfusion and bronchopulmonary dysplasia.
血小板是促血管生成和抗血管生成细胞因子的主要来源。然而，其在早产儿视网膜病变（ROP）中的作用证据存在争议。本回顾性研究旨在比较首 6 周龄时伴有和不伴有 ROP 的婴儿的平均每周血小板计数。共招募了 93 名胎龄和出生体重匹配的婴儿（31 名患有 ROP，62 名无 ROP）。记录了每周平均血小板计数和其他相关危险因素。采用重复测量方差分析（ANOVA）和重复测量协方差分析（ANCOVA）比较两组婴儿在有和没有调整混杂因素的情况下，6 周内的平均血小板计数。我们发现首 6 周龄时伴有和不伴有 ROP 的婴儿的每周平均血小板计数存在显著差异（ = 0.002）。调整混杂因素后，这些差异消失（ = 0.489）。ROP 婴儿的平均血小板计数较低与 ROP 并无直接关系，而是与 ROP 的其他危险因素（如培养阳性败血症、输血和支气管肺发育不良）的存在有关。
