Department of Epidemiology, Gillings School of Global, Public Health University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
J Clin Hypertens (Greenwich). 2018 Feb;20(2):289-296. doi: 10.1111/jch.13171. Epub 2018 Jan 25.
Blood pressure (BP) variability is associated with progression to clinical atherosclerosis. The evidence is inconclusive if BP variability predicts cardiovascular outcomes in low-risk populations. The aim of this study was to analyze the association of 24-hour BP variability with coronary artery calcium (CAC) among a group of individuals without coronary artery disease. The Masked Hypertension Study targeted patients with borderline high BP (120-149 mm Hg systolic and/or 80-95 mm Hg diastolic). Ambulatory blood pressure monitoring (ABPM) was performed at two time-points, 8 days apart. CAC was measured at exit visit via cardiac CT and reported as Agatston Score. Weighted standard deviations and average real variability were calculated from ABPM. Of the 322 participants who underwent cardiac CT, 26% (84) had CAC present, 52% (168) were female, and 21% (64) were black. BP variability did not differ by CAC group. In this low cardiovascular risk group, CAC was not associated with 24-hour ambulatory BP variability.
血压变异性与临床动脉粥样硬化进展有关。如果血压变异性可预测低危人群的心血管结局，那么相关证据尚不一致。本研究旨在分析无冠状动脉疾病人群的 24 小时血压变异性与冠状动脉钙（CAC）之间的关系。掩蔽性高血压研究的目标人群为边缘性高血压患者（收缩压 120-149mmHg 和/或舒张压 80-95mmHg）。在相隔 8 天的两个时间点进行动态血压监测（ABPM）。通过心脏 CT 在退出时测量 CAC，并报告为 Agatston 评分。从 ABPM 计算加权标准差和平均真实变异性。在接受心脏 CT 的 322 名参与者中，26%（84 名）有 CAC 存在，52%（168 名）为女性，21%（64 名）为黑人。CAC 组的血压变异性无差异。在这个低心血管风险人群中，24 小时动态血压变异性与 CAC 无关。
