寨卡病毒的母婴传播：一种引人入胜的相互作用。
Maternal-fetal transmission of the zika virus: An intriguing interplay.
作者信息
Zanluca Camila, de Noronha Lucia, Duarte Dos Santos Claudia Nunes
机构信息
a Laboratório de Virologia Molecular, Instituto Carlos Chagas/Fiocruz-PR , Curitiba , PR , Brazil.
b Laboratório de Patologia Experimental, Pontifícia Universidade Católica do Paraná , Curitiba , PR , Brazil.
出版信息
Tissue Barriers. 2018 Jan 2;6(1):e1402143. doi: 10.1080/21688370.2017.1402143. Epub 2018 Jan 25.
Abstract
In this review, we give an overview of aspects related to the congenital transmission of the Zika virus (ZIKV). Although we acknowledge that important advances in research on ZIKV pathogenesis have come from studies using animal models, particularly non-human primates, this review emphasizes studies using ex-vivo human cells and tissues as well as natural infections in pregnant women. The possible routes used by ZIKV to cross or breach the placental barrier and infect the fetal central nervous system are presented. Understanding the viral infection biology and ZIKV pathogenesis during pregnancy may guide the design of affordable antiviral strategies to benefit pregnant women in areas at risk.
摘要
在本综述中，我们概述了与寨卡病毒（ZIKV）先天性传播相关的各个方面。尽管我们承认，寨卡病毒发病机制的重要研究进展来自使用动物模型的研究，特别是非人类灵长类动物，但本综述强调使用体外人类细胞和组织以及孕妇自然感染的研究。文中介绍了寨卡病毒穿过或突破胎盘屏障并感染胎儿中枢神经系统可能采用的途径。了解孕期病毒感染生物学和寨卡病毒发病机制，可能会指导设计出经济实惠的抗病毒策略，以使处于风险地区的孕妇受益。
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