Lin Xu, Yu Zuxiang, Liu Yang, Li Changzhou, Hu Hui, Hu Jia-Chun, Liu Mian, Yang Qin, Gu Peng, Li Jiaxin, Nandakumar Kutty Selva, Hu Gaofei, Zhang Qi, Chen Xinyu, Ma Huihui, Huang Wenye, Wang Gaofeng, Wang Yan, Huang Liping, Wu Wenjuan, Liu Ning-Ning, Zhang Chenhong, Liu Xingyin, Zheng Leming, Chen Peng
Department of Endocrinology and Metabolism Shunde Hospital of Southern Medical University (The First People's Hospital of Shunde) Foshan City 528308 China.
State Key Laboratory of Vascular Homeostasis and Remodeling, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Health Science Center, The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine Peking University Beijing 100191 China.
Imeta. 2025 Feb 26;4(1):e270. doi: 10.1002/imt2.270. eCollection 2025 Feb.
Recent advances in understanding the modulatory functions of gut and gut microbiota on human diseases facilitated our focused attention on the contribution of the gut to the pathophysiological alterations of many extraintestinal organs, including the liver, heart, brain, lungs, kidneys, bone, skin, reproductive, and endocrine systems. In this review, we applied the "gut-X axis" concept to describe the linkages between the gut and other organs and discussed the latest findings related to the "gut-X axis," including the underlying modulatory mechanisms and potential clinical intervention strategies.
近年来，在理解肠道及肠道微生物群对人类疾病的调节功能方面取得的进展，促使我们将重点关注肠道对许多肠外器官病理生理改变的影响，这些器官包括肝脏、心脏、大脑、肺、肾脏、骨骼、皮肤、生殖系统和内分泌系统。在本综述中，我们应用“肠-X轴”概念来描述肠道与其他器官之间的联系，并讨论了与“肠-X轴”相关的最新研究结果，包括潜在的调节机制和可能的临床干预策略。
