Department of Genomic Medicine, Division of Evolution and Genomic Science, MAHSC, University of Manchester, Central Manchester NHS Foundation Trust, Oxford Road, Manchester, UK.
Nightingale & Prevention Breast Cancer Centre, University Hospital of South Manchester, Manchester, UK.
BMC Public Health. 2018 Jan 25;18(1):178. doi: 10.1186/s12889-018-5090-9.
The differences between breast cancer risk factors in white British/Irish and Asian women attending screening in the UK are not well documented.
Between 2009-15 ethnicity and traditional breast cancer risk factors were self-identified by a screening cohort from Greater Manchester, with follow up to 2016. Risk factors and incidence rates were compared using age-standardised statistics (European standard population).
Eight hundred and seventy-nine Asian women and 51,779 unaffected white British/Irish women aged 46-73 years were recruited. Asian women were at lower predicted breast cancer risk from hormonal and reproductive risk factors than white British/Irish women (mean 10 year risk 2.6% vs 3.1%, difference 0.4%, 95%CI 0.3-0.5%). White British/Irish women were more likely to have had a younger age at menarche, be overweight or obese, taller, used hormone replacement therapy and not to have had children.. However, despite being less overweight Asian women had gained more weight from age 20 years and were less likely to undertake moderate physical activity. Asian women also had a slightly higher mammographic density. Asian age-standardised incidence was 3.2 (95%CI 1.6-5.2, 18 cancers) per thousand women/year vs 4.5 (95%CI 4.2-4.8, 1076 cancers) for white British/Irish women.
Asian women attending screening in Greater Manchester are likely to have a lower risk of breast cancer than white British/Irish women, but they undertake less physical activity and have more adult weight gain.
在英国参加筛查的白种英国/爱尔兰人和亚裔女性的乳腺癌风险因素之间的差异尚未得到充分记录。
在 2009 年至 2015 年期间，大曼彻斯特的筛查队列通过自我识别确定了种族和传统乳腺癌风险因素，并随访至 2016 年。使用年龄标准化统计数据（欧洲标准人口）比较了风险因素和发病率。
共招募了 879 名亚裔女性和 51779 名未受影响的白种英国/爱尔兰女性，年龄在 46-73 岁之间。与白种英国/爱尔兰女性相比，亚裔女性的激素和生殖风险因素导致的乳腺癌预测风险较低（平均 10 年风险为 2.6%，而白种英国/爱尔兰女性为 3.1%，差异为 0.4%，95%CI 为 0.3-0.5%）。白种英国/爱尔兰女性更有可能较早进入青春期、超重或肥胖、更高、使用激素替代疗法且没有生育过。然而，尽管亚裔女性的体重指数更高，但她们的体重增加更多，而且不太可能进行适度的体育锻炼。亚裔女性的乳房 X 光密度也略高。亚洲女性的年龄标准化发病率为每千名女性/年 3.2（95%CI 1.6-5.2，18 例癌症），而白种英国/爱尔兰女性为 4.5（95%CI 4.2-4.8，1076 例癌症）。
在大曼彻斯特参加筛查的亚裔女性患乳腺癌的风险可能低于白种英国/爱尔兰女性，但她们的体育锻炼较少，且成年后体重增加较多。
