组织蛋白酶D对人β-促脂素的作用：人“β-促黑素”的一个可能来源。
Action of cathepsin D on human beta-lipotropin: a possible source of human "beta-melanotropin".
作者信息
Barát E, Patthy A, Gráf L
出版信息
Proc Natl Acad Sci U S A. 1979 Dec;76(12):6120-3. doi: 10.1073/pnas.76.12.6120.
Abstract
Highly purified calf brain cathepsin D (EC 3.4.23.5) selectively splits the Leu77-Phe78 and Ala36-Ala37 peptide bonds of human beta-lipotropin. It is suggested that the formation of human "beta-melanotropin" from gamma-lipotropin, and that of gamma-endorphin from beta-endorphin, is due to the action of cathepsin D during isolation procedures.
摘要
高度纯化的小牛脑组织组织蛋白酶D（EC 3.4.23.5）可选择性地裂解人β-促脂素的Leu77 - Phe78和Ala36 - Ala37肽键。有人提出，γ-促脂素形成人“β-促黑素”以及β-内啡肽形成γ-内啡肽，是由于在分离过程中组织蛋白酶D的作用。
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