Komada Y, Azuma E, Tanaka S, Ochiai H, Sakurai M
Scand J Haematol. 1986 Jan;36(1):85-91. doi: 10.1111/j.1600-0609.1986.tb02655.x.
41 cases of non-T, non-B acute lymphoblastic leukaemia (ALL) were classified by immunological criteria using a panel of monoclonal antibodies against common ALL antigen (cALLa), p24, p20 and HLA-DR antigens. Out of 41 cases, cALLa, p24, p20 and HLA-DR antigens were positive in 31 cases, 34 cases, 35 cases and 41 cases, respectively. 4 cases expressing cytoplasmic mu heavy chains were included in the group of common ALL. We demonstrated that a majority of non-T, non-B ALL would be derived from B-lineage cells. The expression of p24 and p20 was followed by the expression of cALLa and the synthesis of cytoplasmic immunoglobulin. These items of evidence support the idea that the expression of cALLa, p24, p20 and HLA-DR antigens on ALL cells would be universal in the USA, Europe and Japan. Although morphologically identical, non-T, non-B ALL cases could be subdivided into phenotypically-defined subgroups on the basis of cALLa, p24, p20 and HLA-DR antigens.
采用一组针对普通急性淋巴细胞白血病抗原（cALLa）、p24、p20和HLA - DR抗原的单克隆抗体，根据免疫标准对41例非T、非B急性淋巴细胞白血病（ALL）进行分类。在41例病例中，cALLa、p24、p20和HLA - DR抗原呈阳性的分别有31例、34例、35例和41例。4例表达细胞质μ重链的病例被纳入普通ALL组。我们证明，大多数非T、非B ALL起源于B系细胞。p24和p20的表达先于cALLa的表达和细胞质免疫球蛋白的合成。这些证据支持这样一种观点，即在美国、欧洲和日本，ALL细胞上cALLa、p24、p20和HLA - DR抗原的表达具有普遍性。尽管形态相同，但非T、非B ALL病例可根据cALLa、p24、p20和HLA - DR抗原细分为表型定义的亚组。
