Ifrah N, Perrot J Y, Marie J P, Rio B, Julien C, Cadiou M, Boucheix C, Zittoun R
Presse Med. 1985 Jan 26;14(3):137-41.
Between January, 1982 and April, 1983, 92 adult patients with acute leukaemia were investigated in our department. According to classical criteria (cytology and optical cytochemistry), 34 were classified as "non-myeloid". These were further tested with a panel of monoclonal antibodies against cell membrane, including ALB1-2 (anti-CALLA), ALB6 (anti-p24), ALB7-8-9 (BA1), OKT and HLA DR; they were also tested for E rosettes, Slg and terminal transferase (TDT). When all these markers but HLA DR were negative, patients were investigated for ultrastructural peroxidases which were found to be present in 2 cases. Among all non-myeloid leukaemias, 18 (56%) were CALLA-positive and TDT-positive acute lymphoblastic leukaemias (ALL), 2 (6%) were ALL T, 7 (22%) were CALLA-negative and TDT-positive ALL and 5 (16%) were acute leukaemias null for our markers, a phenomenon the significance of which is discussed. Patients with the CALLA-negative TDT-positive phenotype were peculiar with regard to age (mean: 50 years), female predominance, L2 cytological pattern according to the FAB classification, good prognosis (complete remission in 100% of the cases) and median survival (p less than 0,03).
1982年1月至1983年4月期间，我科对92例成年急性白血病患者进行了研究。根据经典标准（细胞学和光学细胞化学），34例被归类为“非髓系”。这些患者进一步用一组针对细胞膜的单克隆抗体进行检测，包括ALB1 - 2（抗CALLA）、ALB6（抗p24）、ALB7 - 8 - 9（BA1）、OKT和HLA DR；他们还检测了E玫瑰花结、表面免疫球蛋白（Slg）和末端转移酶（TDT）。当所有这些标志物（除HLA DR外）均为阴性时，对患者进行超微结构过氧化物酶检测，发现2例存在该酶。在所有非髓系白血病中，18例（56%）为CALLA阳性和TDT阳性的急性淋巴细胞白血病（ALL），2例（6%）为T细胞ALL，7例（22%）为CALLA阴性和TDT阳性的ALL，5例（16%）为我们检测的标志物均为阴性的急性白血病，本文讨论了这一现象的意义。具有CALLA阴性TDT阳性表型的患者在年龄（平均：50岁）、女性占优势、根据FAB分类为L2细胞学模式、预后良好（100%病例完全缓解）和中位生存期（p小于0.03）方面具有特殊性。
