From the Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109.
From the Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109
J Biol Chem. 2018 Apr 13;293(15):5396-5403. doi: 10.1074/jbc.R117.804641. Epub 2018 Jan 25.
Autophagy is a highly conserved catabolic pathway that is vital for development, cell survival, and the degradation of dysfunctional organelles and potentially toxic aggregates. Dysregulation of autophagy is associated with cancer, neurodegeneration, and lysosomal storage diseases. Accordingly, autophagy is precisely regulated at multiple levels (transcriptional, post-transcriptional, translational, and post-translational) to prevent aberrant activity. Various model organisms are used to study autophagy, but the baker's yeast continues to be advantageous for genetic and biochemical analysis of non-selective and selective autophagy. In this Minireview, we focus on the cellular mechanisms that regulate autophagy transcriptionally and post-transcriptionally in .
自噬是一种高度保守的分解代谢途径，对于发育、细胞存活以及功能失调的细胞器和潜在毒性聚集体的降解至关重要。自噬的失调与癌症、神经退行性疾病和溶酶体贮积病有关。因此，自噬在多个水平（转录、转录后、翻译和翻译后）受到精确调节，以防止异常活性。各种模式生物被用于研究自噬，但面包酵母仍然有利于非选择性和选择性自噬的遗传和生化分析。在这篇综述中，我们重点讨论了调节酵母中自噬转录和转录后水平的细胞机制。
