Life Sciences Institute and Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.
Cell Death Differ. 2023 Jun;30(6):1416-1429. doi: 10.1038/s41418-023-01162-9. Epub 2023 Apr 12.
Macroautophagy/autophagy is a conserved catabolic pathway that is vital for maintaining cell homeostasis and promoting cell survival under stressful conditions. Dysregulation of autophagy is associated with a variety of human diseases, such as cancer, neurodegenerative diseases, and metabolic disorders. Therefore, this pathway must be precisely regulated at multiple levels, involving epigenetic, transcriptional, post-transcriptional, translational, and post-translational mechanisms, to prevent inappropriate autophagy activity. In this review, we focus on autophagy regulation at the transcriptional level, summarizing the transcription factors that control autophagy gene expression in both yeast and mammalian cells. Because the expression and/or subcellular localization of some autophagy transcription factors are altered in certain diseases, we also discuss how changes in transcriptional regulation of autophagy are associated with human pathophysiologies.
自噬是一种保守的分解代谢途径，对于维持细胞内环境平衡和促进应激条件下的细胞存活至关重要。自噬的失调与多种人类疾病有关，如癌症、神经退行性疾病和代谢紊乱。因此，该途径必须在多个水平上进行精确调控，涉及表观遗传、转录、转录后、翻译和翻译后机制，以防止不适当的自噬活性。在这篇综述中，我们重点关注转录水平的自噬调控，总结了控制酵母和哺乳动物细胞自噬基因表达的转录因子。由于某些自噬转录因子的表达和/或亚细胞定位在某些疾病中发生改变，我们还讨论了自噬转录调控的变化如何与人类病理生理学相关。
