Bertuzzi Margherita, Hayes Gemma E, Icheoku Uju J, van Rhijn Norman, Denning David W, Osherov Nir, Bignell Elaine M
Manchester Fungal Infection Group, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9NT, UK.
Northern Devon Healthcare NHS Trust, North Devon District Hospital, Raleigh Park, Barnstaple EX31 4JB, UK.
J Fungi (Basel). 2018 Jan 8;4(1):8. doi: 10.3390/jof4010008.
Respiratory epithelia fulfil multiple roles beyond that of gaseous exchange, also acting as primary custodians of lung sterility and inflammatory homeostasis. Inhaled fungal spores pose a continual antigenic, and potentially pathogenic, challenge to lung integrity against which the human respiratory mucosa has developed various tolerance and defence strategies. However, respiratory disease and immune dysfunction frequently render the human lung susceptible to fungal diseases, the most common of which are the aspergilloses, a group of syndromes caused by inhaled spores of . Inhaled spores enter into a multiplicity of interactions with respiratory epithelia, the mechanistic bases of which are only just becoming recognized as important drivers of disease, as well as possible therapeutic targets. In this mini-review we examine current understanding of -epithelial interactions and, based upon the very latest developments in the field, we explore two apparently opposing schools of thought which view epithelial uptake of spores as either a curative or disease-exacerbating event.
呼吸上皮细胞除了进行气体交换外，还发挥着多种作用，同时也是肺部无菌状态和炎症稳态的主要守护者。吸入的真菌孢子对肺部完整性构成持续的抗原性以及潜在致病性挑战，人类呼吸道黏膜针对此已发展出多种耐受和防御策略。然而，呼吸系统疾病和免疫功能障碍常常使人类肺部易患真菌疾病，其中最常见的是曲霉病，这是一组由吸入 的孢子引起的综合征。吸入的 孢子与呼吸上皮细胞发生多种相互作用，其机制基础才刚刚被认为是疾病的重要驱动因素以及可能的治疗靶点。在本综述中，我们审视了当前对 -上皮细胞相互作用的理解，并基于该领域的最新进展，探讨了两种明显对立的观点，这两种观点将上皮细胞摄取 孢子视为治愈性或疾病加重性事件。
