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DLAT subunit of the pyruvate dehydrogenase complex is upregulated in gastric cancer-implications in cancer therapy.丙酮酸脱氢酶复合体的DLAT亚基在胃癌中上调——对癌症治疗的启示
Am J Transl Res. 2015 Jun 15;7(6):1140-51. eCollection 2015.
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An overview of recent advances in structural bioinformatics of protein-protein interactions and a guide to their principles.蛋白质-蛋白质相互作用的结构生物信息学最新进展概述及其原理指南。
Prog Biophys Mol Biol. 2014 Nov-Dec;116(2-3):141-50. doi: 10.1016/j.pbiomolbio.2014.07.004. Epub 2014 Jul 29.
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E-cadherin mediates adhesion and endocytosis of Aspergillus fumigatus blastospores in human epithelial cells.E-钙黏蛋白介导烟曲霉分生孢子在人上皮细胞中的黏附和内吞作用。
Chin Med J (Engl). 2012 Feb;125(4):617-21.
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Strategies to harness immunity against infectious pathogens after haploidentical stem cell transplantation.同种异体造血干细胞移植后针对感染病原体的免疫策略。
Am J Transl Res. 2011;3(5):404-21. Epub 2011 Sep 10.
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Prediction of protein-protein interactions: unifying evolution and structure at protein interfaces.预测蛋白质-蛋白质相互作用：在蛋白质界面上统一进化和结构。
Phys Biol. 2011 Jun;8(3):035006. doi: 10.1088/1478-3975/8/3/035006. Epub 2011 May 13.
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Curr Opin Struct Biol. 2011 Jun;21(3):382-90. doi: 10.1016/j.sbi.2011.03.013. Epub 2011 Apr 14.
7
Inducible expression of beta defensins by human respiratory epithelial cells exposed to Aspergillus fumigatus organisms.暴露于烟曲霉的人呼吸道上皮细胞对β-防御素的诱导表达。
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N-terminal E-cadherin peptides act as decoy receptors for Listeria monocytogenes.N 端 E-钙黏蛋白肽作为单核细胞增生李斯特菌的诱饵受体。
Infect Immun. 2003 Mar;71(3):1580-3. doi: 10.1128/IAI.71.3.1580-1583.2003.
10
Participation of complement in the phagocytosis of the conidia of Aspergillus fumigatus by human polymorphonuclear cells.补体在人多形核细胞对烟曲霉分生孢子的吞噬作用中的参与。
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重要因素通过E-钙黏蛋白介导烟曲霉与肺泡上皮细胞的黏附。

Important factors mediates the adhesion of aspergillus fumigatus to alveolar epithelial cells with E-cadherin.

作者信息

Xu Xiao-Yong, Chen Fei, Sun He, Chen Chen, Zhao Bei-Lei

机构信息

Department of Respiratory Medicine, Nanjing General Hospital of Nanjing Military Command, PLA Nanjing, Jiangsu, China.

出版信息

Am J Transl Res. 2016 May 15;8(5):2419-25. eCollection 2016.

PMID:27347350
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4891455/
Abstract

Aspergillus is widely distributed in the Earth's biosphere. It has strong adaptive capacity, and lives as saprophytic or parasitic life. This study aims to investigate the role of E-cadherin for adhesion of Aspergillus fumigatus blastospores in a human epithelial cell line (A549) and search the correlated molecule in aspergillus. A. fumigatus blastospores were incubated with the total protein of A549 to investigate the binding of E-cadherin and blastospores followed by an affinity purification procedure. After establishing the adhesion model, the adhesion of A. fumigatus blastospores by A549 cells was evaluated by down-regulating E-cadherin of A549 cells with small interfering RNA (siRNA). FVB mice constructed with E-cadherin down-regulation were infected with aspergillus fumigatus. Preliminary exploration of E-cadherin interacting protein on the surface of aspergillus fumigates by immunoprecipitation and mass spectrometry analysis. E-cadherin was adhered to the surface of A. fumigatus blastospore. Adhesion of the blastospores was reduced by blocking or down-regulating E-cadherin in A549 cells. E-cadherin showed limited significance in the process of mice against aspergillus fumigates. Mass spectrometry (MS) analysis indicated the following proteins AFUA_8G07080, AfA24A6.130c, XP_747789 can bind to E-cadherin. In conclusion, E-cadherin is a receptor for adhesion of A. fumigatus blastospores in epithelial cells. This may open a new approach to treat this fungal infection.

摘要

曲霉菌广泛分布于地球生物圈。它具有很强的适应能力，以腐生或寄生方式生存。本研究旨在探讨E-钙黏蛋白在烟曲霉芽生孢子黏附人上皮细胞系（A549）中的作用，并寻找曲霉菌中的相关分子。将烟曲霉芽生孢子与A549的总蛋白孵育，通过亲和纯化程序研究E-钙黏蛋白与芽生孢子的结合。建立黏附模型后，用小干扰RNA（siRNA）下调A549细胞的E-钙黏蛋白，评估A549细胞对烟曲霉芽生孢子的黏附。构建E-钙黏蛋白下调的FVB小鼠，用烟曲霉感染。通过免疫沉淀和质谱分析初步探索烟曲霉表面与E-钙黏蛋白相互作用的蛋白。E-钙黏蛋白黏附于烟曲霉芽生孢子表面。在A549细胞中阻断或下调E-钙黏蛋白可降低芽生孢子的黏附。E-钙黏蛋白在小鼠抗烟曲霉过程中意义有限。质谱（MS）分析表明，AFUA_8G07080、AfA24A6.130c、XP_747789等蛋白可与E-钙黏蛋白结合。总之，E-钙黏蛋白是上皮细胞中烟曲霉芽生孢子黏附的受体。这可能为治疗这种真菌感染开辟新途径。