Vedrine Bertrand, Fribourg-Blanc Luc-André
From the Clinique Vétérinaire Seinevet, 5 Place Cauchoise, 76000 Rouen, France.
J Am Anim Hosp Assoc. 2018 Mar/Apr;54(2):103-110. doi: 10.5326/JAAHA-MS-6648. Epub 2018 Jan 26.
Rhinoscopy was performed on 10 dogs with sinonasal aspergillosis (SNA). Direct access to the sinus via the nasal ostium was possible with a flexible endoscope to allow sinuscopy. Debridement of fungal plaques in the frontal sinus and the nasal cavity was performed, and a sinus and nasal deposition therapy with clotrimazole (1%) cream was made under rhinoscopic guidance. No oral medication was administered following the procedure. A rhinoscopic follow-up was performed monthly until cure. Six of ten (60%) dogs presented fungal plaques in the nasal cavity and in the frontal sinus and 4/10 (40%) dogs presented fungal plaques only in the frontal sinus. Five of ten (50%) dogs were considered to be cured at the first follow-up rhinoscopy, 4/10 (40%) after the second follow-up, and 1/10 (10%) after the third. Two dogs had delayed recurrence of SNA rhinoscopically assessed 12 and 21 mo, respectively, after the last clotrimazole treatment. Endoscopic debridement of fungal plaques and clotrimazole (1%) cream deposition therapy seems to be a valuable minimally invasive technique for SNA treatment in dogs without the use of complementary oral medication. Delayed recurrence is a potential finding following treatment of SNA.
对10只患有鼻窦曲霉菌病（SNA）的犬进行了鼻镜检查。使用柔性内窥镜可经鼻道直接进入鼻窦以进行鼻窦镜检查。对额窦和鼻腔内的真菌斑块进行清创，并在鼻镜引导下用克霉唑（1%）乳膏进行鼻窦和鼻腔给药治疗。术后未给予口服药物。每月进行一次鼻镜随访直至治愈。10只犬中有6只（60%）在鼻腔和额窦出现真菌斑块，4只（40%）仅在额窦出现真菌斑块。10只犬中有5只（50%）在首次鼻镜随访时被认为治愈，第二次随访后4只（40%）治愈，第三次随访后1只（10%）治愈。在最后一次克霉唑治疗后，分别于12个月和21个月通过鼻镜检查评估发现2只犬出现SNA延迟复发。内镜下真菌斑块清创和克霉唑（1%）乳膏给药治疗似乎是一种有价值的微创技术，可用于犬SNA的治疗，且无需使用辅助口服药物。延迟复发是SNA治疗后的一个潜在发现。
