de Jong Judith E, Heuvelink Annet E, Dieste Pérez Lucía, Holstege Manon M C
Department Cattle Health, Royal GD, P.O. Box 9, 7400 AA Deventer, the Netherlands.
Department Research and Development, Royal GD, P.O. Box 9, 7400 AA Deventer, the Netherlands.
Med Mycol. 2025 Jan 25;63(2). doi: 10.1093/mmy/myaf009.
Aspergillosis in humans and animals is caused by certain Aspergillus spp. and can be treated with fungicide azoles. Treatment in animals is often long and complicated by the lack of registered products, species-specific pharmacodynamics, side effects, and withdrawal periods for animal products. The emergence of azole resistance in Aspergillus spp. isolates from human, environmental, and avian samples is alarming, requiring multisectoral attention and a One Health approach. Recent information on the prevalence and impact of aspergillosis in animals, and the use of fungicide azoles in their treatment is however lacking. In this study, we collected and analysed data on the occurrence of aspergillosis and/or presence of Aspergillus spp., and the use of fungicide azoles in animal categories in Europe over the last decade, by means of an international survey and literature review. Thirty-three survey responses were included, from respondents with various professional backgrounds. Fifty-eight articles were included for literature review, of which 90% contained information on the presence of Aspergillus spp. in diseased or healthy animals and 38% on the veterinary use of azoles. Results were consistent: the presence of Aspergillus spp. and related disease, and the use of fungicide azoles were most frequently reported in 'companion animals' and 'zoo animals and wildlife'. Considering the limitations in interpreting the obtained results and the lack of available data, more consistent data collection is necessary to accurately estimate the importance of Aspergillus spp. and related diseases, the use of azoles in veterinary medicine, and its relevance in public health.
人类和动物的曲霉病由某些曲霉菌种引起，可用唑类杀菌剂治疗。动物治疗通常疗程长，且因缺乏注册产品、物种特异性药效学、副作用以及动物产品的停药期而变得复杂。从人类、环境和禽类样本中分离出的曲霉菌种出现唑类耐药性令人担忧，需要多部门关注并采取“同一健康”方法。然而，目前缺乏关于动物曲霉病的流行情况和影响以及唑类杀菌剂在其治疗中的使用的最新信息。在本研究中，我们通过国际调查和文献综述，收集并分析了过去十年欧洲动物类别中曲霉病的发生情况和/或曲霉菌种的存在情况以及唑类杀菌剂的使用数据。纳入了33份来自不同专业背景受访者的调查回复。纳入了58篇文章进行文献综述，其中90%包含患病或健康动物中曲霉菌种存在情况的信息，38%包含唑类在兽医领域使用情况的信息。结果是一致的：曲霉菌种的存在及相关疾病以及唑类杀菌剂的使用在“伴侣动物”和“动物园动物及野生动物”中报告得最为频繁。考虑到解释所得结果存在的局限性以及可用数据的缺乏，需要更一致的数据收集来准确估计曲霉菌种及相关疾病的重要性、唑类在兽医学中的使用及其与公共卫生的相关性。
