Merot Y, Gravallese E, Guillén F J, Murphy G F
Arch Dermatol. 1986 Apr;122(4):455-8.
Toxic epidermal necrolysis is a life-threatening disease, the pathogenesis of which remains largely unknown. Histologically, in addition to the characteristic epidermal alterations, there is a sparse mononuclear cell infiltrate in the dermis. The immunologic characteristics of this infiltrate are not well known. In a case of drug-induced toxic epidermal necrolysis with fatal outcome in a 48-year-old man, we demonstrated that the majority of the inflammatory cells were of helper/inducer T-lymphocyte subsets, having only a minority of cytotoxic/suppressor T-lymphocytes and rare cells with natural killer cell phenotype. The significance of these observations is discussed, with reference to the occurrence of lesions at epithelial sites bearing local networks of antigen-presenting cells (Langerhans' cells).
中毒性表皮坏死松解症是一种危及生命的疾病，其发病机制在很大程度上仍不清楚。组织学上，除了特征性的表皮改变外，真皮中有稀疏的单核细胞浸润。这种浸润的免疫特征尚不清楚。在一名48岁男性发生的药物性中毒性表皮坏死松解症致死病例中，我们证明大多数炎症细胞是辅助/诱导性T淋巴细胞亚群，只有少数细胞毒性/抑制性T淋巴细胞，以及罕见的具有自然杀伤细胞表型的细胞。结合在上皮部位出现带有局部抗原呈递细胞网络（朗格汉斯细胞）的病变情况，对这些观察结果的意义进行了讨论。
