Ghofraniha Leila, Amini Mahnaz, Davoudi Yasamin, Eslami Saeed, Layegh Parvin, Lotfi Zahra, Firouzi Farnoush, Khajehnasiri Samaneh
Department of Lung Diseases, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Radiology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Acta Med Iran. 2017 Dec;55(12):765-771.
In recent decades, the relation of carotid artery intima-media thickness (IMT) as a marker of atherosclerosis with snoring and sleep disorders has been drawing attention. The aim of this study was to evaluate the relation of carotid arteries IMT with snoring in type 2 diabetic patients. This cross-sectional study was performed on type 2 diabetes patients referring to Mashhad University of Medical Sciences' clinics. The stop Bang, Epworth sleepiness scale, and Stanford questionnaires were used for evaluation of daily sleepiness and snoring. For assessment of carotid artery thickness, Madison X8 ultrasound with 10 MHz superficial probes was utilized. The data were entered into SPSS software, and then the ANOVA test with Turkey, chi-square comparison technique, and Kruskal Wallis with Mann-Whitney U technique was used. The level of significance was considered P≤0.05. In total 80 patients (37 snorers and 43 non-snorers) entered the study. The mean carotid artery IMT in the group of snoring patients (0.72±0.17) was significantly higher than non-snorers (0.56±0.17) (P<0.001). Frequency of daily based on Stanford and ESS questionnaires was 23.8% and 39.2%. The association of sleepiness and snoring was confirmed by Stanford and ESS questionnaires with P=0.026 and P=0.007. Patients with higher risk of apnea had higher thickness of the mean carotid artery IMT (P<0.001). The mean carotid artery IMT had a positive significant relation with age (P=0.002), serum creatinine level (P<0.002), blood cholesterol (P=0.02) and HbAIC level (P=0.04). Findings of this study provides evidence on the relation of carotid artery IMT in diabetic patients with snoring independent of other effective factors. Also, results showed that snoring is associated with increased daily sleepiness and patients with higher risk of apnea had higher thickness of the mean carotid artery IMT.
近几十年来，作为动脉粥样硬化标志物的颈动脉内膜中层厚度（IMT）与打鼾及睡眠障碍之间的关系一直备受关注。本研究旨在评估2型糖尿病患者颈动脉IMT与打鼾之间的关系。这项横断面研究是在转诊至马什哈德医科大学诊所的2型糖尿病患者中进行的。采用阻塞性睡眠呼吸暂停低通气综合征（OSA）筛查问卷、爱泼华嗜睡量表（ESS）和斯坦福问卷来评估日常嗜睡和打鼾情况。为评估颈动脉厚度，使用了配备10MHz浅表探头的麦迪逊X8超声仪。数据录入SPSS软件，然后采用Turkey方差分析检验、卡方比较技术以及Kruskal Wallis检验和Mann-Whitney U检验技术。显著性水平设定为P≤0.05。共有80名患者（37名打鼾者和43名非打鼾者）进入研究。打鼾患者组的平均颈动脉IMT（0.72±0.17）显著高于非打鼾者（0.56±0.17）（P<0.001）。基于斯坦福问卷和ESS问卷的每日嗜睡频率分别为23.8%和39.2%。斯坦福问卷和ESS问卷证实嗜睡与打鼾之间存在关联，P值分别为0.026和0.007。呼吸暂停风险较高的患者平均颈动脉IMT厚度更高（P<0.001）。平均颈动脉IMT与年龄（P=0.002）、血清肌酐水平（P<0.002）、血胆固醇（P=0.02）和糖化血红蛋白（HbA1c）水平（P=0.04）呈显著正相关。本研究结果为糖尿病患者颈动脉IMT与打鼾之间的关系提供了证据，且独立于其他影响因素。此外，结果表明打鼾与每日嗜睡增加有关，呼吸暂停风险较高的患者平均颈动脉IMT厚度更高。
