Mack D O, Lewis E M, Butler E M, Archer W H, Smith L D
Biochem Med. 1985 Dec;34(3):327-34. doi: 10.1016/0006-2944(85)90095-x.
A comparison was made of succinyladenylate lyase (SAMP lyase), total serum sialic (TSA), and lipid soluble serum sialic acid (LSA) as early markers of malignancy in three experimentally induced rat tumor models. Elevation of SAMP lyase in 3'-methyl-dimethylaminoazobenzene-induced hepatic tumors at 2 weeks corresponded with microscopic detection of preneoplastic lesions with elevation of LSA occurring 2 weeks later. Elevation of breast SAMP lyase concurred with macroscopic presence of dimethylbenzanthracene involved breast tumors with elevation of LSA occurring 12 weeks later. Neither colon SAMP lyase nor LSA increased in rats bearing colon tumors induced by dimethylhydrazine. The determination of TSA was not a reliable indicator of tumor presence for the three types of tumors investigated. Both SAMP lyase and LSA are very good early indicators of hepatic tumor with SAMP lyase an earlier indicator of breast tumor than LSA.
在三种实验诱导的大鼠肿瘤模型中，对琥珀酰腺苷酸裂解酶（SAMP裂解酶）、总血清唾液酸（TSA）和脂溶性血清唾液酸（LSA）作为恶性肿瘤早期标志物进行了比较。在3'-甲基-二甲基氨基偶氮苯诱导的肝肿瘤中，2周时SAMP裂解酶升高与癌前病变的显微镜检测结果一致，2周后LSA升高。乳腺SAMP裂解酶升高与二甲基苯并蒽所致乳腺肿瘤的肉眼可见情况一致，12周后LSA升高。在携带二甲基肼诱导的结肠肿瘤的大鼠中，结肠SAMP裂解酶和LSA均未升高。对于所研究的三种肿瘤类型，TSA的测定并非肿瘤存在的可靠指标。SAMP裂解酶和LSA都是肝肿瘤的良好早期指标，SAMP裂解酶是比LSA更早的乳腺肿瘤指标。
