Keller Diana, Sundrum Albert
Department of Animal Health and Animal Nutrition, University of Kassel, Witzenhausen, Germany.
Vet Rec. 2018 Apr 7;182(14):407. doi: 10.1136/vr.104555. Epub 2018 Jan 26.
Based on the widespread use of homeopathy in dairy farm practice when treating mastitis, a blind randomised controlled trial (RCT) was conducted to assess the effectiveness of homeopathic treatment of clinical mastitis on four dairy farms. The study considered specific guidelines for RCTs as well as the basic principles of individualised homeopathy and involved 180 lactating dairy cows. Evaluation of cure rates was based on clinical investigation of the udder and on laboratory analysis of milk samples. In culture-positive cases, the antibiotic treatment provided suboptimal bacteriological cures (60-81 per cent) but was more effective than individualised homeopathy (33-43 per cent) whose effects appeared little different to those of placebos (45-47 per cent) (P≤0.05). On the cytological cure level, all three treatment methods were similarly ineffective: antibiotic being 2-21 per cent, individualised homeopathy 0-8 per cent and placebo 3-13 per cent (P≤0.05; P=0.13). Antibiotics, individualised homeopathy and placebo had similar effects on bacteriological and cytological cure in cases of culture-negative milk samples (P>0.4) and infections (P=1.0). The study results implied that the effectiveness of individualised homeopathy does not go beyond a placebo effect and successful treatment is highly dependent on the specific mastitis pathogen. Thus, antimicrobial or alternative remedies used should be based on the bacterial culture of the milk sample.
NTP-ID: 00008011-1-9, Pre-results.
鉴于顺势疗法在奶牛场治疗乳腺炎实践中的广泛应用，开展了一项双盲随机对照试验（RCT），以评估顺势疗法治疗四个奶牛场临床乳腺炎的有效性。该研究考虑了RCT的具体指南以及个体化顺势疗法的基本原则，涉及180头泌乳奶牛。治愈率的评估基于乳房的临床检查和牛奶样本的实验室分析。在培养阳性的病例中，抗生素治疗的细菌学治愈率不理想（60%-81%），但比个体化顺势疗法更有效（33%-43%），其效果与安慰剂（45%-47%）的效果差异不大（P≤0.05）。在细胞学治愈水平上，三种治疗方法同样无效：抗生素为2%-21%，个体化顺势疗法为0%-8%，安慰剂为3%-13%（P≤0.05；P=0.13）。在培养阴性的牛奶样本病例（P>0.4）和感染病例（P=1.0）中，抗生素、个体化顺势疗法和安慰剂对细菌学和细胞学治愈的效果相似。研究结果表明，个体化顺势疗法的有效性不超过安慰剂效应，成功治疗高度依赖于特定的乳腺炎病原体。因此，所使用的抗菌药物或替代疗法应基于牛奶样本的细菌培养。
NTP-ID：00008011-1-9，预结果。
