Tomanić Dragana, Samardžija Marko, Kovačević Zorana
Department of Veterinary Medicine, Faculty of Agriculture, University of Novi Sad, Trg Dositeja Obradovica 8, 21000 Novi Sad, Serbia.
Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, 10000 Zagreb, Croatia.
Antibiotics (Basel). 2023 Mar 30;12(4):683. doi: 10.3390/antibiotics12040683.
Despite preventive and therapeutic measures, mastitis continues to be the most prevalent health problem in dairy herds. Considering the risks associated with antibiotic therapy, such as compromised effectiveness due to the emergence of resistant bacteria, food safety issues, and environmental impact, an increasing number of scientific studies have referred to the new therapeutic procedures that could serve as alternatives to conventional therapy. Therefore, the aim of this review was to provide insight into the currently available literature data in the investigation of non-antibiotic alternative approaches. In general, a vast number of in vitro and in vivo available data offer the comprehension of novel, effective, and safe agents with the potential to reduce the current use of antibiotics and increase animal productivity and environmental protection. Constant progress in this field could overcome treatment difficulties associated with bovine mastitis and considerable global pressure being applied on reducing antimicrobial therapy in animals.
尽管采取了预防和治疗措施，但乳腺炎仍然是奶牛群中最普遍的健康问题。考虑到抗生素治疗相关的风险，如耐药菌出现导致疗效受损、食品安全问题以及环境影响，越来越多的科学研究提到了可作为传统治疗替代方法的新治疗程序。因此，本综述的目的是深入了解目前关于非抗生素替代方法研究的文献数据。总体而言，大量现有的体外和体内数据有助于理解新型、有效且安全的药物，这些药物有可能减少目前抗生素的使用，并提高动物生产力和环境保护水平。该领域的不断进步可以克服与牛乳腺炎相关的治疗困难，以及全球在减少动物抗菌治疗方面所面临的巨大压力。
