a Laboratory of Stem Cell and Tissue Engineering, State Key Laboratory of Biotherapy , West China Hospital, Sichuan University , Chengdu , P.R. China.
b Department of Orthopedics , West China Hospital, Sichuan University , Chengdu , P.R. China.
J Biomater Sci Polym Ed. 2018 Apr;29(6):663-682. doi: 10.1080/09205063.2018.1433419. Epub 2018 Feb 2.
Abdominal wall defects are a common medical problem, and inadequate repair methods can lead to serious complications. Abdominal wall reconstruction using autologous tissue, or non-biological, biological, or composite patches is often performed to repair defective areas. In particular, composite patches containing both polymeric and biological materials have gained increasing attention due to their good mechanical properties and biocompatibility. However, it is still unclear whether the quality of repairs using composite patches is superior to that of a biological patch. Based on the limitations of previous studies, we compared small intestinal submucosa (SIS) patches with SIS + polypropylene mesh (PPM) patches for repairing abdominal wall defects in adult beagle dogs. Forty-five female dogs were subjected to surgical resection to produce abdominal wall defects. SIS or SIS + PPM was used as patch for the defects. Morphology, biomechanics, and histological evaluations were performed to evaluate the efficacy and safety of such therapies. Our findings demonstrated that SIS had advantages over SIS + PPM considering biological activity and histocompatibility without increasing the risk of repair failure.
腹壁缺损是一种常见的医学问题，如果修复方法不当，可能会导致严重的并发症。自体组织（或非生物、生物或复合补片）常被用于修复有缺陷的区域，以进行腹壁重建。特别是，含有聚合物和生物材料的复合补片因其良好的机械性能和生物相容性而受到越来越多的关注。然而，使用复合补片修复的质量是否优于生物补片，目前仍不清楚。基于以往研究的局限性，我们比较了小型猪的小肠黏膜下层（SIS）补片与 SIS+聚丙烯网（PPM）补片修复成年比格犬腹壁缺损的效果。45 只雌性比格犬接受了手术切除以产生腹壁缺损。使用 SIS 或 SIS+PPM 作为补片修复缺陷。通过形态学、生物力学和组织学评估来评估这些治疗方法的疗效和安全性。我们的研究结果表明，与 SIS+PPM 相比，SIS 具有更好的生物活性和组织相容性，而不会增加修复失败的风险。
