Hosoyama Katsuhiro, Kawamoto Shunsuke, Kumagai Kiichiro, Akiyama Masatoshi, Adachi Osamu, Kawatsu Satoshi, Saiki Yoshikatsu
Division of Cardiovascular Surgery, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Ann Thorac Cardiovasc Surg. 2018 Apr 20;24(2):89-96. doi: 10.5761/atcs.oa.17-00138. Epub 2018 Jan 26.
Selective cerebral perfusion with the open proximal technique for thoracoabdominal aortic repair has not been conclusively validated because of its procedural complexity and unreliability. We report the clinical outcomes, particularly the cerebroneurological complications, of an open proximal procedure using selective cerebral perfusion.
A retrospective chart review identified 30 patients between 2007 and 2015 who underwent aortic repair through left lateral thoracotomy with selective cerebral perfusion, established through endoluminal brachiocephalic and left carotid artery and retrograde left axillary artery.
The mean durations of the open proximal procedure and cerebral ischemia (the duration of the open proximal procedure minus the duration of selective cerebral perfusion) were 110.3 ± 40.1 min and 24.8 ± 13.0 min, respectively. There were two cases (7%) of permanent neurologic dysfunction (PND) but no in-hospital deaths. Multivariate analysis identified the duration of cerebral ischemia as an independent risk factor for neurologic complications including temporary neurologic dysfunction (TND; odds ratio (OR): 1.13; p = 0.007), but no correlation was found between selective cerebral perfusion duration and neurologic complications.
Despite the relatively long duration of the open proximal procedure, selective cerebral perfusion has a potential to protect against cerebral complications during thoracic aortic repair through a left lateral thoracotomy.
用于胸腹主动脉修复的开放近端技术选择性脑灌注,因其操作复杂性和不可靠性尚未得到最终验证。我们报告了使用选择性脑灌注的开放近端手术的临床结果,特别是脑神经系统并发症。
一项回顾性图表审查确定了2007年至2015年间30例患者,他们通过左外侧开胸手术进行主动脉修复,并通过腔内头臂动脉和左颈动脉以及逆行左腋动脉建立选择性脑灌注。
开放近端手术和脑缺血的平均持续时间(开放近端手术持续时间减去选择性脑灌注持续时间)分别为110.3±40.1分钟和24.8±13.0分钟。有2例(7%)永久性神经功能障碍(PND),但无住院死亡病例。多变量分析确定脑缺血持续时间是包括短暂性神经功能障碍(TND)在内的神经并发症的独立危险因素(优势比(OR):1.13;p=0.007),但未发现选择性脑灌注持续时间与神经并发症之间存在相关性。
尽管开放近端手术持续时间相对较长,但选择性脑灌注有可能在通过左外侧开胸进行胸主动脉修复期间预防脑并发症。