Department of Internal Medicine, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
Department of Medical Ultrasound, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
Dis Markers. 2017;2017:5286408. doi: 10.1155/2017/5286408. Epub 2017 Dec 10.
Cathepsin D has been recently implicated in insulin resistance and cardiovascular disease. This study was designed to investigate the relationship between cathepsin D and newly diagnosed type 2 diabetes.
Circulating cathepsin D levels and metabolic variables were measured in 98 cases and 98 controls. Myocardial performance index "Tei index" that reflects both left ventricular systolic and diastolic function was measured with Doppler echocardiography in cases.
Newly diagnosed type 2 diabetes demonstrated significantly higher circulating cathepsin D concentrations than controls (median level: 227 ng/ml versus 174 ng/ml, < 0.01). In newly diagnosed type 2 diabetes, a significant correlation was found between cathepsin D levels and HOMA-IR (homeostatic model assessment of insulin resistance) ( = 0.25, = 0.01). In contrast, no significant correlation was found between cathepsin D levels and clinical parameters in the control group (all > 0.05). Interestingly, correlation analysis revealed a positive association between cathepsin D levels and Tei index in type 2 diabetes ( = 0.22, = 0.03).
Increased levels of circulating cathepsin D are closely linked with the presence of type 2 diabetes, and cathepsin D might serve as a novel biomarker for cardiac dysfunction in newly diagnosed type 2 diabetes.
组织蛋白酶 D 最近与胰岛素抵抗和心血管疾病有关。本研究旨在探讨组织蛋白酶 D 与新诊断 2 型糖尿病之间的关系。
在 98 例病例和 98 例对照中测量了循环组织蛋白酶 D 水平和代谢变量。在病例中使用多普勒超声心动图测量反映左心室收缩和舒张功能的心肌性能指数“Tei 指数”。
新诊断的 2 型糖尿病患者的循环组织蛋白酶 D 浓度明显高于对照组（中位数水平：227ng/ml 与 174ng/ml，<0.01）。在新诊断的 2 型糖尿病中，组织蛋白酶 D 水平与 HOMA-IR（胰岛素抵抗的稳态模型评估）之间存在显著相关性（=0.25，=0.01）。相比之下，对照组中组织蛋白酶 D 水平与临床参数之间没有显著相关性（均>0.05）。有趣的是，相关性分析显示 2 型糖尿病患者组织蛋白酶 D 水平与 Tei 指数呈正相关（=0.22，=0.03）。
循环组织蛋白酶 D 水平升高与 2 型糖尿病的发生密切相关，组织蛋白酶 D 可能是新诊断 2 型糖尿病患者心脏功能障碍的新型生物标志物。
