Oral Surgery Department, Dental School, University of Seville, Seville, Spain.
Mediators Inflamm. 2017;2017:7460780. doi: 10.1155/2017/7460780. Epub 2017 Dec 10.
To evaluate the effectiveness on tissue response of the new nutritional supplement made of oligomeric proanthocyanidins in induced gingivitis after 21 days of use.
A prospective, double-blind, randomized, controlled clinical trial was carried out on 20 patients; it is divided into an experimental group and a control group after fulfilling the selection criteria. Patients had to come 4 times during the study to register the Silness and Löe index, the gingival bleeding index, the plaque index, the inflammatory crevicular fluid study (IL6), and the changes in the brightness of the gingiva. No complementary hygiene methods were allowed during the 21 days.
The Silness and Löe index was higher in the control group than in the experimental group, reaching a twofold difference between the groups ( < 0.0001). The gingival bleeding index also supports this fact, since the bleeding was lower in the experimental group ( < 0.005). However, the dental plaque on the tooth surface according to the plaque index was 33% higher in the experimental group ( < 0.006). Some differences in the IL-6 were found in the crevicular fluid ( < 0.0001).
Oligomeric proanthocyanidins have an effect on the periodontal tissue's health. No effects on the accumulation of plaque on the tooth surface were found, so further studies are needed to determine the nature of the plaque.
评估新型低聚原花青素营养补充剂在诱导性牙龈炎 21 天后对组织反应的有效性。
对 20 名患者进行了一项前瞻性、双盲、随机、对照临床试验；满足选择标准后将患者分为实验组和对照组。在研究期间，患者必须来 4 次记录 Silness 和 Löe 指数、牙龈出血指数、菌斑指数、炎症性龈沟液研究（IL6）以及牙龈亮度变化。在 21 天内不允许使用任何补充性的口腔卫生方法。
对照组的 Silness 和 Löe 指数高于实验组，两组之间存在两倍差异（<0.0001）。牙龈出血指数也支持这一事实，因为实验组的出血较低（<0.005）。然而，根据菌斑指数，实验组的牙面菌斑增加了 33%（<0.006）。在龈沟液中发现了一些 IL-6 的差异（<0.0001）。
低聚原花青素对牙周组织健康有影响。但对牙面菌斑的堆积没有影响，因此需要进一步研究以确定菌斑的性质。
