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伴有包括缺失在内的复杂核型的弥漫性大B细胞淋巴瘤的白血病期及脑脊液受累情况

Leukemic phase and CSF involvement of diffuse large B-cell lymphoma with a complex karyotype including a deletion.

作者信息

Sinkoff Jillian, Olteanu Horatiu, Peterson Jess F, Shah Nirav N

机构信息

Department of Medicine Medical College of Wisconsin Milwaukee Wisconsin.

Department of Pathology Froedtert/MCW Laboratory Building Milwaukee Wisconsin.

出版信息

Clin Case Rep. 2017 Dec 5;6(1):235-237. doi: 10.1002/ccr3.1250. eCollection 2018 Jan.

DOI:10.1002/ccr3.1250
PMID:29375876
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5771872/
Abstract

Diffuse large B-cell lymphoma in rare instances can present initially in a leukemic phase and mimic other lymphoid diseases. In such cases, advanced diagnostic testing including immunophenotyping, FISH analysis, and karyotyping can help determine the accurate diagnosis which is key in the management of the disease.

摘要

弥漫性大B细胞淋巴瘤在罕见情况下最初可表现为白血病期，并可模仿其他淋巴样疾病。在这种情况下，包括免疫表型分析、荧光原位杂交（FISH）分析和核型分析在内的先进诊断检测有助于确定准确诊断，这是该疾病管理的关键。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2284/5771872/0c365b72994c/CCR3-6-235-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2284/5771872/0c365b72994c/CCR3-6-235-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2284/5771872/0c365b72994c/CCR3-6-235-g001.jpg

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BMC Med Genet. 2017 Feb 16;18(1):16. doi: 10.1186/s12881-017-0381-z.
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A Clinical Triad with Fatal Implications: Recrudescent Diffuse Large B-cell Non-Hodgkin Lymphoma Presenting in the Leukemic Phase with an Elevated Serum Lactic Acid Level and Dysregulation of the TP53 Tumor Suppressor Gene - A Case Report and Literature Review.
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Clin Med Insights Blood Disord. 2021 Feb 19;14:2634853521994094. doi: 10.1177/2634853521994094. eCollection 2021.
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Hematol Transfus Cell Ther. 2020 Apr-Jun;42(2):180-183. doi: 10.1016/j.htct.2019.04.005. Epub 2019 Jul 23.