糖尿病患者与非糖尿病患者角膜感染危险因素的比较研究。
A comparative study of risk factors for corneal infection in diabetic and non-diabetic patients.
作者信息
Wang Bin, Yang Shuo, Zhai Hua-Lei, Zhang Yang-Yang, Cui Chun-Xia, Wang Jun-Yi, Xie Li-Xin
机构信息
Shandong University, Jinan 250100, Shandong Province, China.
Qingdao Eye Hospital, Shandong Eye Institute, Shandong Academy of Medical Sciences, Qingdao 266071, Shandong Province, China.
出版信息
Int J Ophthalmol. 2018 Jan 18;11(1):43-47. doi: 10.18240/ijo.2018.01.08. eCollection 2018.
AIM
To compare the clinical characteristics of infectious keratopathy in type 2 diabetes mellitus (T2DM) and non-diabetes mellitus (NDM) and to investigate risk factors for infectious keratopathy in T2DM patients.
METHODS
Totally 230 patients with T2DM and 168 with NDM diagnosed as infectious keratopathy were hospitalized at Qingdao Eye Hospital from 2001 to 2015. Data including sex, age, occupation, season, smoking and alcohol consumption habits, duration between onset and treatments, duration of hospitalization were collected. Initially identified indicators were analyzed with a multivariate logistic regression. Glycosylated hemoglobin A1c (HbA1c) in patients with T2DM was analyzed. The infectious keratopathies in the two groups were categorized and compared.
RESULTS
The diabetic group consisted of 146 (63.5%) males and 84 (36.5%) females. The NDM group consisted of 111 (66.1%) males and 57 (33.9%) females. There was no signigicantly difference in sex distribution between the two groups (>0.05). There were significant differences in age, occupation of patients, season of the onset of diseases, duration between onset and treatment, and durations of hospitalization between the two groups (<0.05). In most of the patients in the diabetic group, the duration between onset and treatment was ≤3mo, and most was ≥3mo in the NDM group. Multivariate logistic regression analysis revealed that age and season were related to the development of corneal infection in the T2DM group (OR=1.709, 1.706). In the T2DM group, HbA1c was 9.09%±2.12%. There were statistically significant differences in the incidences of bacterial keratitis and herpes simplex keratitis in the two groups (<0.05), but no significant statistical difference was found between fungal keratitis and amoebic keratitis (>0.05).
CONCLUSION
Advanced age and the summer and winter seasons are identified as risk factors for infectious keratopathy in T2DM patients, and T2DM patients are more prone to bacterial keratitis.
目的
比较2型糖尿病（T2DM）患者与非糖尿病（NDM）患者感染性角膜病的临床特征，并探讨T2DM患者感染性角膜病的危险因素。
方法
2001年至2015年期间，青岛眼科医院收治了230例诊断为感染性角膜病的T2DM患者和168例NDM患者。收集患者的性别、年龄、职业、季节、吸烟和饮酒习惯、发病至治疗的时间、住院时间等数据。对初步确定的指标进行多因素逻辑回归分析。分析T2DM患者的糖化血红蛋白A1c（HbA1c）。对两组的感染性角膜病进行分类并比较。
结果
糖尿病组男性146例（63.5%），女性84例（36.5%）。NDM组男性111例（66.1%），女性57例（33.9%）。两组性别分布无显著差异（>0.05）。两组患者的年龄、职业、发病季节、发病至治疗的时间以及住院时间存在显著差异（<0.05）。糖尿病组大多数患者发病至治疗的时间≤3个月，而NDM组大多数患者发病至治疗的时间≥3个月。多因素逻辑回归分析显示，年龄和季节与T2DM组角膜感染的发生有关（OR = 1.709，1.706）。T2DM组的HbA1c为9.09%±2.12%。两组细菌性角膜炎和单纯疱疹性角膜炎的发病率存在统计学显著差异（<0.05），但真菌性角膜炎和阿米巴性角膜炎之间无显著统计学差异（>0.05）。
结论
高龄以及夏季和冬季被确定为T2DM患者感染性角膜病的危险因素，且T2DM患者更容易发生细菌性角膜炎。
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