Wang Ye, Zhou Qingjun, Xie Lixin
Shandong Provincial Key Lab of Ophthalmology, Shandong Eye Institute, Qingdao 266071, China.
Shandong Provincial Key Lab of Ophthalmology, Shandong Eye Institute, Qingdao 266071, China. Email:
Zhonghua Yan Ke Za Zhi. 2014 Jan;50(1):69-72.
The incidence of diabetes mellitus and its complications, including diabetic keratopathy, was significantly elevated with the improved living standards in China recently. Diabetic keratopathy mainly exhibited several clinical features, including the delay of corneal epithelial regeneration, the decreasing of corneal sensitivity, neurotrophic corneal ulcers. The features were mainly caused by the changes of corneal epithelial basement membrane compositions, glycation products deposition, corneal nerve ending damage, reduced tear secretion and oxidative stress in the hyperglycemic conditions. This review focuses on the progress of molecular and cellular mechanism related with the clinical features, and discusses the main problems in the basic research of diabetic keratopathy.
近年来，随着中国生活水平的提高，糖尿病及其并发症（包括糖尿病角膜病变）的发病率显著上升。糖尿病角膜病变主要表现为几种临床特征，包括角膜上皮再生延迟、角膜敏感性降低、神经营养性角膜溃疡。这些特征主要是由高血糖条件下角膜上皮基底膜成分的变化、糖基化产物沉积、角膜神经末梢损伤、泪液分泌减少和氧化应激引起的。本文综述了与这些临床特征相关的分子和细胞机制的研究进展，并讨论了糖尿病角膜病变基础研究中的主要问题。
