Li Xiang-Ji, Xie Lin, Pan Fu-Sheng, Wang Yong, Liu Hong, Tang Yu-Rong, Hutnik Cindy Ml
Department of Ophthalmology, University of Western Ontario, Ivey Eye Institute, St. Joseph's Hospital, 268 Grosvenor Street, London, ON N6A 4V2, Canada.
Department of Ophthalmology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China.
Int J Ophthalmol. 2018 Jan 18;11(1):135-142. doi: 10.18240/ijo.2018.01.21. eCollection 2018.
Technological advances in glaucoma have challenged the traditional treatment paradigm. Historically incisional surgery has been used in cases of advanced disease and/or uncontrolled intraocular pressures resistant to medical or laser interventions. More recently, perhaps due to advancements in imaging, surgery has been suggested to be beneficial earlier in the treatment paradigm. Despite these trends, surgical manipulation of the tissues and unpredictability of wound healing continue to result in surgical failure. Magnesium is an essential element for human body and plays a critically important role in maintaining the functional and structural integrity of several tissues, including the eye. Due to several of its advantageous properties such as non-toxicity, biodegradability, and high biological compatibility, magnesium alloy has attracted great attention as a novel biomaterial. Biodegradable cardiovascular stents made of magnesium alloy have already been introduced into clinical practice. The purpose of this review is to determine if bioabsorbable magnesium alloys can be utilized as a promising candidate for the development of a new generation of glaucoma surgical assistive devices.
青光眼领域的技术进步对传统治疗模式提出了挑战。从历史上看，切开手术一直用于晚期疾病和/或对药物或激光干预有抵抗性的眼压控制不佳的病例。最近，也许是由于成像技术的进步，有人建议在治疗模式中更早地进行手术会有益处。尽管有这些趋势，但组织的手术操作和伤口愈合的不可预测性仍然导致手术失败。镁是人体必需的元素，在维持包括眼睛在内的多种组织的功能和结构完整性方面起着至关重要的作用。由于镁合金具有无毒、可生物降解和高生物相容性等多种有利特性，它作为一种新型生物材料引起了极大关注。由镁合金制成的可生物降解心血管支架已经被引入临床实践。这篇综述的目的是确定可生物吸收镁合金是否可以作为开发新一代青光眼手术辅助装置的有前景的候选材料。
