Technische Universität Berlin, Berlin, Germany.
Department of Materials Engineering, Institute of Technology Berlin, Str. des 17. Juni 135 - Sekr. EB 13, 10623, Berlin, Germany.
Biometals. 2019 Apr;32(2):185-193. doi: 10.1007/s10534-019-00170-y. Epub 2019 Jan 18.
The study of innovative biodegradable implant materials is one of the most interesting research topics at the forefront in the area of biomaterials. Biodegradable implant materials in the human body can be gradually dissolved, absorbed, consumed or excreted, so there is no need for the secondary surgery to remove implants after the surgery regions have healed. However, most of the biodegradable materials, usually polymers, do not have good mechanical properties to be reliable for bearing the load of the body. Magnesium and its alloys due to the excellent biodegradability and biocompatibility as well as the suitable mechanical compatibility with human bone are very promising candidates for the development of temporary, degradable implants in load-bearing applications. However, Mg alloys are corrosion susceptible in a biological environment. Besides, the high corrosion rate and the low bioactivity of magnesium implants are the challenging problems, which need to be resolved before employing them in clinical applications. This paper provides a review of state-of-the-art of magnesium alloy implants for orthopedic and tissue engineering applications and describes recent progress in the design of novel structure design Mg alloys and potential approaches to improve their biodegradation performance.
可生物降解植入材料的研究是生物材料领域最前沿的研究课题之一。在人体内可生物降解的植入材料会逐渐溶解、吸收、消耗或排出，因此在手术部位愈合后无需进行二次手术取出植入物。然而，大多数可生物降解材料（通常为聚合物）的机械性能不佳，无法可靠地承受身体的负荷。镁及其合金由于具有优异的生物降解性和生物相容性，以及与人体骨骼相适应的机械相容性，是开发用于承载应用的临时可降解植入物的极具前景的候选材料。然而，镁合金在生物环境中容易腐蚀。此外，镁植入物的高腐蚀速率和低生物活性是在临床应用之前需要解决的挑战问题。本文综述了用于骨科和组织工程应用的镁合金植入物的最新研究进展，并介绍了新型结构设计镁合金的设计和提高其生物降解性能的潜在方法的最新进展。
