Denko C W, Aponte J, Gabriel P, Petricevic M
Clin Rheumatol. 1986 Jan;5(1):25-32. doi: 10.1007/BF02030964.
In 120 patients with rheumatic disorders concomitant assays of serum and synovial fluid were done for acute phase reactants, immunoglobulins and the neuropeptide beta-endorphin. One-third of the patients with rheumatoid disease demonstrated synovial fluid levels of endorphin to be several-fold higher than serum levels, while in two-thirds the opposite results were found. These changes are discussed as adaptive or defense mechanisms. The synovial membrane is postulated to synthesize beta-endorphin.
对120例患有风湿性疾病的患者同时进行了血清和滑液检测，以测定急性期反应物、免疫球蛋白和神经肽β-内啡肽。三分之一的类风湿病患者滑液中的内啡肽水平比血清水平高几倍，而三分之二的患者则出现相反结果。这些变化被认为是适应性或防御性机制。推测滑膜可合成β-内啡肽。
