滑液和血清样本中亚硝酸盐浓度升高表明风湿性疾病中一氧化氮合成增加。
Increased concentrations of nitrite in synovial fluid and serum samples suggest increased nitric oxide synthesis in rheumatic diseases.
作者信息
Farrell A J, Blake D R, Palmer R M, Moncada S
机构信息
Inflammation Research Group, London Hospital Medical College, Whitechapel, United Kingdom.
出版信息
Ann Rheum Dis. 1992 Nov;51(11):1219-22. doi: 10.1136/ard.51.11.1219.
Abstract
Cytokines induce nitric oxide synthesis by endothelial cells, macrophages and polymorphonuclear leucocytes, indicating a role for nitric oxide in inflammatory processes. Nitric oxide production was therefore measured indirectly as nitrite in serum and synovial fluid samples from patients with rheumatoid arthritis (RA) and osteoarthritis (OA) together with serum samples from healthy volunteers matched for age and sex. Serum nitrite concentrations in patients with RA and OA were significantly higher than in controls. In both disease groups synovial fluid nitrite was significantly higher than serum nitrite, implying nitric oxide synthesis by the synovium. Serum and synovial fluid nitrite concentrations in RA were also significantly higher than those in OA. These data show increased nitric oxide production in RA and OA and suggest a role for nitric oxide as an inflammatory mediator in rheumatic diseases.
摘要
细胞因子可诱导内皮细胞、巨噬细胞和多形核白细胞合成一氧化氮，这表明一氧化氮在炎症过程中发挥作用。因此，我们间接测量了类风湿性关节炎（RA）和骨关节炎（OA）患者血清和滑液样本中的亚硝酸盐含量，以此来测定一氧化氮的生成量，同时还测量了年龄和性别匹配的健康志愿者的血清样本。RA和OA患者的血清亚硝酸盐浓度显著高于对照组。在这两个疾病组中，滑液中的亚硝酸盐含量均显著高于血清中的亚硝酸盐含量，这意味着滑膜可合成一氧化氮。RA患者血清和滑液中的亚硝酸盐浓度也显著高于OA患者。这些数据表明，RA和OA中一氧化氮生成增加，提示一氧化氮在风湿性疾病中作为炎症介质发挥作用。
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Ann Rheum Dis. 1992 Nov;51(11):1219-22. doi: 10.1136/ard.51.11.1219.
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