Instrumental Analysis Center of Xi'an Jiaotong University , Xi'an 710049, P. R. China.
Bioconjug Chem. 2018 Feb 21;29(2):559-570. doi: 10.1021/acs.bioconjchem.8b00053. Epub 2018 Feb 9.
Liver cancer is currently among the most challenging cancers to diagnose and treat. It is of prime importance to minimize the side effects on healthy tissues and reduce drug resistance for precise diagnoses and effective treatment of liver cancer. Herein, we report a facile but high-yield approach to fabricate a multifunctional nanomaterial through the loading of chitosan and metformin on Mn-doped FeO@MoS nanoflowers. Mn-doped FeO cores are used as simultaneous T/T magnetic resonance imaging (MRI) agents for sensitive and accurate cancer diagnosis, while MoS nanosheets are used as effective near-infrared photothermal conversion agents for potential photothermal therapy. The surface-functionalized chitosan was able not only to improve the dispersibility of Mn-doped FeO@MoS nanoflowers in biofluids and increase their biocompatibility, but also to significantly enhance the photothermal effect. Furthermore, metformin loading led to high suppression and eradication of hepatoma cells when photothermally sensitized, but exhibited negligible effects on normal liver cells. Due to its excellent combination of T/T MRI properties with sensitive chemotherapeutic and photothermal effects, our study highlights the promise of developing multifunctional nanomaterials for accurate multimodal imaging-guided, and highly sensitive therapy of liver cancer.
肝癌是目前诊断和治疗最具挑战性的癌症之一。对于肝癌的精确诊断和有效治疗，最大限度地减少对健康组织的副作用和降低药物耐药性至关重要。在此，我们报告了一种通过壳聚糖和二甲双胍负载到 Mn 掺杂的 FeO@MoS 纳米花上制备多功能纳米材料的简便但高产的方法。Mn 掺杂的 FeO 核用作 T1/T2 磁共振成像（MRI）试剂，用于灵敏和准确的癌症诊断，而 MoS 纳米片用作有效的近红外光热转换试剂，用于潜在的光热治疗。表面功能化的壳聚糖不仅能够提高 Mn 掺杂的 FeO@MoS 纳米花在生物流体中的分散性并提高其生物相容性，而且还能够显著增强光热效应。此外，当光热敏化时，二甲双胍负载导致肝癌细胞的高抑制和根除，但对正常肝细胞几乎没有影响。由于其 T1/T2 MRI 特性与敏感化疗和光热效应的出色结合，我们的研究强调了开发多功能纳米材料用于肝癌的精确多模态成像引导和高灵敏度治疗的前景。
