Sharma Ashima, Bhalothia Dinesh, Vankayala Raviraj, Bagaria Ashima
Department of Physics, Manipal University Jaipur, Rajasthan, 303007, India.
Department of Electronics and Communication Engineering, Manipal University Jaipur, Rajasthan, 303007, India.
Sci Rep. 2025 Jul 18;15(1):26028. doi: 10.1038/s41598-025-09648-x.
In this study, we report the synthesis and photothermal evaluation of polymer-functionalized molybdenum disulfide (MoS₂) nanoplatforms with distinct morphologies; three-dimensional (3D) nanoflowers (MNF) and two-dimensional (2D) nanorods (MNR), tailored for targeted drug delivery applications. The MoS₂ nanostructures were synthesized via a hydrothermal route by modulating the sulfur precursor, yielding morphology-dependent growth. The resulting nanostructures were subsequently functionalized with polyethylene glycol (PEG) and polyethyleneimine (PEI), producing MNF@PEG@PEI (MFPP) and MNR@PEG@PEI (MRPP) platforms. Comprehensive characterization via FESEM, FTIR, and XRD confirmed the formation of distinct morphologies, effective polymer functionalization through amine and carboxyl groups, and the coexistence of 1T/2H MoS₂ phases. Photothermal properties were evaluated under 808 nm NIR laser irradiation. MFPP demonstrated a photothermal conversion efficiency of 46.86%, significantly higher than the 19.94% observed for MRPP. Moreover, functionalization enhanced the temperature elevation in MNF from 10.2 °C to 14.5 °C, whereas MNR showed minimal improvement (5.0 °C to 5.6 °C). This performance enhancement in MFPP is attributed to its porous, multi-layered architecture, which facilitates higher NIR absorption via multiple internal reflections and active defect sites. These findings highlight MFPP as a promising candidate for photothermal and photoacoustic imaging-guided drug delivery, reinforcing the importance of morphological and surface-engineering strategies in designing next-generation MoS₂-based nanocarriers for cancer therapy.
在本研究中，我们报告了具有不同形态的聚合物功能化二硫化钼（MoS₂）纳米平台的合成及光热评估；为靶向药物递送应用量身定制的三维（3D）纳米花（MNF）和二维（2D）纳米棒（MNR）。通过调节硫前驱体，采用水热法合成了MoS₂纳米结构，实现了形态依赖生长。随后，用聚乙二醇（PEG）和聚乙烯亚胺（PEI）对所得纳米结构进行功能化，制备了MNF@PEG@PEI（MFPP）和MNR@PEG@PEI（MRPP）平台。通过场发射扫描电子显微镜（FESEM）、傅里叶变换红外光谱（FTIR）和X射线衍射（XRD）进行的综合表征证实了不同形态的形成、通过胺基和羧基实现的有效聚合物功能化以及1T/2H MoS₂相的共存。在808 nm近红外激光照射下评估了光热性能。MFPP的光热转换效率为46.86%，显著高于MRPP的19.94%。此外，功能化使MNF的温度升高从10.2℃提高到14.5℃，而MNR的改善极小（从5.0℃提高到5.6℃）。MFPP的这种性能提升归因于其多孔的多层结构，该结构通过多次内部反射和活性缺陷位点促进了更高的近红外吸收。这些发现突出了MFPP作为光热和光声成像引导药物递送的有前景候选者，强化了形态和表面工程策略在设计用于癌症治疗的下一代基于MoS₂的纳米载体中的重要性。
