Järnfelt-Samsioe A, Bremme K, Eneroth P
Eur J Obstet Gynecol Reprod Biol. 1986 Feb;21(2):87-99. doi: 10.1016/0028-2243(86)90047-x.
Nausea and/or vomiting in early pregnancy is common enough to be generally accepted as normal or 'physiological'. The specific etiology of these complaints is still obscure. One possibility is that endocrine factors may play some part. In this study, 102 healthy pregnant women, of whom 62 complained of nausea, were followed throughout pregnancy and the circulating levels of cortisol, testosterone, dehydroepiandrosterone sulphate (DHEA-S), progesterone, oestradiol and total and free oestriol were measured. In early pregnancy, serum levels of cortisol and progesterone were significantly lower in emetic subjects. In the last trimester, significantly higher DHEA-S concentrations and lower testosterone values were found in women who had suffered from nausea and vomiting in early pregnancy compared to asymptomatic subjects. Overt differences were found between emetic and non-emetic pregnancy and it is concluded that endocrine factors are of etiological importance in emesis gravidarum.
妊娠早期出现恶心和/或呕吐的情况很常见，以至于通常被认为是正常的或“生理性的”。这些症状的具体病因仍不清楚。一种可能性是内分泌因素可能起到一定作用。在本研究中，对102名健康孕妇进行了全程跟踪，其中62名孕妇诉说有恶心症状，并检测了她们血液中皮质醇、睾酮、硫酸脱氢表雄酮（DHEA-S）、孕酮、雌二醇以及总雌三醇和游离雌三醇的水平。在妊娠早期，有呕吐症状的孕妇血清皮质醇和孕酮水平显著较低。在妊娠晚期，与无症状的孕妇相比，早期有恶心呕吐症状的孕妇DHEA-S浓度显著较高，而睾酮值较低。有呕吐症状和无呕吐症状的孕妇之间存在明显差异，由此得出结论，内分泌因素在妊娠呕吐的病因中具有重要意义。
