Jarnfelt-Samsioe A
Obstet Gynecol Surv. 1987 Jul;42(7):422-7. doi: 10.1097/00006254-198707000-00003.
Throughout pregnancy, women with nausea and vomiting in early pregnancy showed a different metabolic pattern compared to asymptomatic pregnancies. Women suffering from nausea and vomiting seem to have a low "functional reserve" of their liver capacity and could tentatively be described as hypersensitive to estrogens or their metabolites, e.g., catecholestrogens. These steroids have "emetic" properties, which might be explained by their direct stimulation of area postrema. It is known that estrogens increase the brain's excitability. Another possible mechanism could be by interacting with liver metabolism, resulting in the production of irregular metabolites, which in turn possess "emetic" qualities.
在整个孕期，与无恶心呕吐症状的孕妇相比，孕早期出现恶心呕吐的女性呈现出不同的代谢模式。患有恶心呕吐的女性肝脏功能储备似乎较低，可初步描述为对雌激素或其代谢产物（如儿茶酚雌激素）高度敏感。这些类固醇具有“催吐”特性，这可能是由于它们直接刺激最后区所致。已知雌激素会增加大脑的兴奋性。另一种可能的机制是与肝脏代谢相互作用，导致产生不规则代谢产物，进而具有“催吐”性质。
