用于同时递送红曲黄色素和白藜芦醇的植物双分子层包裹酪蛋白胶束
Phytosomal bilayer-enveloped casein micelles for codelivery of monascus yellow pigments and resveratrol to breast cancer.
机构信息
Cancer Nanotechnology Research Laboratory (CNRL), Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt.
Department of Biotechnology, Institute of Graduate Studies & Research, Alexandria University, Alexandria 21526, Egypt.
出版信息
Nanomedicine (Lond). 2018 Mar;13(5):481-499. doi: 10.2217/nnm-2017-0301. Epub 2018 Jan 29.
AIM
Multireservoir nanocarriers were fabricated for delivering antineoplastic drug cocktail from herbal and fungal origin. Monascus yellow pigments (MYPs), monascin and ankaflavin, were isolated from red-mold rice, and incorporated within casein micelles (CAS MCs) along with the herbal drug, resveratrol (RSV). Both drugs (MYPs and RSV) were simultaneously incorporated into the hydrophobic core of CAS MCs. Alternatively, MYPs-loaded CAS MCs were enveloped within RSV-phytosomal bilayer elaborating multireservoir nanocarriers.
RESULTS
Cytotoxicity studies confirmed the superiority of multireservoir nanocarriers against MCF-7 breast cancer cells. The in vivo antitumor efficacy was revealed by reduction of the tumor volume and growth biomarkers.
CONCLUSION
Multireservoir CAS nanocarriers for codelivery of both MYPs and RSV may be promising alternative to traditional breast cancer therapy.
目的
制备多储库纳米载体，用于递送源自植物和真菌的抗肿瘤药物鸡尾酒。从红曲米中分离出红曲黄色素（MYP）、monascin 和ankaflavin，并与植物药白藜芦醇（RSV）一起掺入酪蛋白胶束（CAS MCs）中。两种药物（MYP 和 RSV）同时被掺入 CAS MCs 的疏水核心中。或者，用 RSV-植物双层包裹负载 MYP 的 CAS MCs，以制备多储库纳米载体。
结果
细胞毒性研究证实了多储库纳米载体对 MCF-7 乳腺癌细胞的优越性。体内抗肿瘤疗效通过降低肿瘤体积和生长标志物来揭示。
结论
多储库 CAS 纳米载体共递送 MYP 和 RSV 可能是传统乳腺癌治疗的有前途的替代方法。
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