Kapoor Devesh U, Prajapati Bhupendra G, Bhattacharya Sankha, Singhai Nidhi Jain, Maheshwari Rahul
Dr. Dayaram Patel Pharmacy College, Sardar Baug, Station Road, Surat 394601, Gujarat, India.
Shree S.K. Patel College of Pharmaceutical Education and Research, Ganpat University, Mehsana 384012, Gujarat, India.
Curr Pharm Des. 2025;31(23):1844-1865. doi: 10.2174/0113816128338217250114073640.
The field of drug delivery has witnessed significant advancements with the emergence of nanocarriers and advanced delivery devices for parenteral administration. Nanocarriers, a prominent topic in drug delivery, are introduced with an emphasis on their significance and diverse applications A critical analysis compares conventional injectables with parenteral nanocarriers, focusing on identifying limitations and proposing innovative solutions to enhance their efficacy and stability. The subsequent discussion delves into advanced parenteral nanocarriers, including solid lipid nanoparticles, liposomes, polymeric nanoparticles, metallic nanoparticles, dendrimers, carbon nanotubes, and graphene. Each nanoparticle type is assessed based on its unique properties, advancements in research, and potential applications in parenteral drug delivery. Furthermore, advanced sterile drug delivery devices are explored, highlighting their role in enhancing precision and efficacy in parenteral administration. A comprehensive market analysis provides insights into current trends, key players, and future prospects in parenteral nanocarriers. Lastly, regulatory perspectives are discussed, focusing on the challenges and considerations in approving and regulating parenteral nanocarriers. The paper concludes with a summary of key findings and implications for future research and development in this rapidly evolving field of parenteral nanocarriers.
随着纳米载体和用于肠胃外给药的先进给药装置的出现,药物递送领域取得了显著进展。纳米载体作为药物递送中的一个重要主题,在介绍时强调了其重要性和多样的应用。一项批判性分析将传统注射剂与肠胃外纳米载体进行了比较,重点在于识别局限性并提出创新解决方案以提高其疗效和稳定性。随后的讨论深入探讨了先进的肠胃外纳米载体,包括固体脂质纳米粒、脂质体、聚合物纳米粒、金属纳米粒、树枝状大分子、碳纳米管和石墨烯。每种纳米粒类型都基于其独特性质、研究进展以及在肠胃外药物递送中的潜在应用进行了评估。此外,还探讨了先进的无菌药物递送装置,突出了它们在提高肠胃外给药的精准度和疗效方面的作用。一项全面的市场分析提供了关于肠胃外纳米载体当前趋势、主要参与者和未来前景的见解。最后,讨论了监管方面的观点,重点在于批准和监管肠胃外纳米载体的挑战和考量因素。本文最后总结了关键发现以及对这个快速发展的肠胃外纳米载体领域未来研发的启示。