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甲癣:综述

Onychomycosis: A Review.

作者信息

Piraccini Bianca Maria, Alessandrini Aurora

机构信息

Division of Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Via Massarenti 1, 40138 Bologna, Italy.

出版信息

J Fungi (Basel). 2015 Mar 27;1(1):30-43. doi: 10.3390/jof1010030.

DOI:10.3390/jof1010030
PMID:29376897
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5770011/
Abstract

Onychomycosis is the most common nail infective disorder. It is caused mainly by anthropophilic dermatophytes, in particular by and var. . Yeasts, like and , and molds, like spp, represent the second cause of onychomycosis. The clinical suspect of onychomycosis should be confirmed my mycology. Onychoscopy is a new method that can help the physician, as in onychomycosis, it shows a typical fringed proximal margin. Treatment is chosen depending on the modality of nail invasion, fungus species and the number of affected nails. Oral treatments are often limited by drug interactions, while topical antifungal lacquers have less efficacy. A combination of both oral and systemic treatment is often the best choice.

摘要

甲癣是最常见的指甲感染性疾病。它主要由亲人性皮肤癣菌引起,特别是由[具体菌种1][具体菌种2]变种引起。酵母菌,如[酵母菌1]和[酵母菌2],以及霉菌,如[霉菌菌种],是甲癣的第二大病因。甲癣的临床疑似病例应由真菌学检查确诊。甲下镜检查是一种新方法,可帮助医生诊断,因为在甲癣中,它显示出典型的边缘呈流苏状的近端边缘。治疗方法的选择取决于指甲感染的方式、真菌种类以及受影响指甲的数量。口服治疗常常受到药物相互作用的限制,而外用抗真菌指甲油的疗效较差。口服和外用治疗相结合通常是最佳选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cee/5770011/74542764cd8b/jof-01-00030-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cee/5770011/3adaa5fc8f0d/jof-01-00030-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cee/5770011/74542764cd8b/jof-01-00030-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cee/5770011/3adaa5fc8f0d/jof-01-00030-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cee/5770011/74542764cd8b/jof-01-00030-g010.jpg

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本文引用的文献

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1,064-nm diode laser therapy of onychomycosis: results of a prospective open treatment of 82 toenails.1064纳米二极管激光治疗甲癣:82个趾甲前瞻性开放治疗结果
Dermatology. 2015;230(2):128-34. doi: 10.1159/000368348. Epub 2015 Feb 3.
2
Aspergillus species as emerging causative agents of onychomycosis.曲霉属作为甲癣的新兴致病原。
J Mycol Med. 2015 Jun;25(2):101-7. doi: 10.1016/j.mycmed.2014.12.001. Epub 2015 Feb 2.
3
Efinaconazole topical solution, 10%: the benefits of treating onychomycosis early.10% 艾氟康唑外用溶液:早期治疗甲癣的益处。
通过聚合酶链反应-限制性片段长度多态性(PCR-RFLP)和聚合酶链反应-真菌特异性引物(PCR-FSP)方法对从指甲标本中分离出的酵母群落进行分子鉴定。
Curr Med Mycol. 2024 May 7;10:e2024.345184.1539. doi: 10.22034/cmm.2024.345237.1539. eCollection 2024.
4
Multidrug-resistant keratinolytic dermatophytes and non-dermatophytes causing onychomycosis in outpatients.引起门诊患者甲癣的多重耐药角质分解性皮肤癣菌和非皮肤癣菌
Future Microbiol. 2025 Feb;20(2):137-147. doi: 10.1080/17460913.2024.2428140. Epub 2024 Nov 26.
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The refractory nailbed ulceration caused by after nail extraction.拔甲后导致的难治性甲床溃疡
Med Mycol Case Rep. 2024 Oct 15;46:100677. doi: 10.1016/j.mmcr.2024.100677. eCollection 2024 Dec.
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New Diagnostic Strategy for Onychomycosis: First-Line Utilization of DermaGenius PCR and Calcofluor Microscopy Combined with Selective Culturing.甲癣的新诊断策略:DermaGenius聚合酶链反应和荧光白显微镜检查联合选择性培养的一线应用
J Fungi (Basel). 2024 Jul 24;10(8):515. doi: 10.3390/jof10080515.
7
Clinical and epidemiological study of onychomycosis among patients of the national institute of hygiene in rabat, Morocco (2016-2020).摩洛哥拉巴特国家卫生研究所患者甲癣的临床与流行病学研究(2016 - 2020年)
Curr Med Mycol. 2023 Dec;9(4):39-46. doi: 10.22034/CMM.2024.345174.1492.
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J Clin Aesthet Dermatol. 2024 Mar;17(3):24-33.
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Clinico-Mycological Study of Onychomycosis in Indian Diabetic Patients.印度糖尿病患者甲癣的临床真菌学研究
Indian Dermatol Online J. 2023 Oct 17;14(6):807-813. doi: 10.4103/idoj.idoj_642_22. eCollection 2023 Nov-Dec.
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Novel Henna-Related Naphthazarine Photosensitizers for an Effective Photodynamic Therapy of Onychomycosis.用于甲癣有效光动力治疗的新型指甲花相关萘并萘醌光敏剂。
ACS Pharmacol Transl Sci. 2023 Nov 22;6(12):1958-1971. doi: 10.1021/acsptsci.3c00259. eCollection 2023 Dec 8.
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Comparison of the efficacy of long-pulsed Nd:YAG laser intervention for treatment of onychomycosis of toenails or fingernails.长脉冲Nd:YAG激光干预治疗趾甲或指甲甲真菌病的疗效比较。
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The role of topical antifungal therapy for onychomycosis and the emergence of newer agents.局部抗真菌治疗在甲真菌病中的作用及新型药物的出现。
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