Blutfield Matthew S, Lohre Jenna M, Pawich Derek A, Vlahovic Tracey C
Temple University School of Podiatric Medicine, 148 N. 8th St., Philadelphia, PA 19107, USA.
J Fungi (Basel). 2015 Jul 17;1(2):130-137. doi: 10.3390/jof1020130.
Manifestations of infestations, such as tinea pedis, tinea cruris, and tinea corporis, are among the most common human skin diseases seen throughout the world. About 80% of patients presenting with acute dermatophytosis respond well to topical antifungal treatment. However, the remaining 20% of patients progress into a chronic state of dermatophytosis, which is resistant to antifungal treatment. Therefore, it is necessary to have a better understanding and appreciation for the diverse immune responses to Trichophyton as this is critical for the development of therapeutic strategies for those individuals who suffer from a chronic manifestation of () infection. As a result, a comprehensive literature review was conducted to review and discuss previous studies that evaluated the human body's defense to infections and to understand why and how these fungal infections invade the host defense system. Our research revealed that a cell-mediated immune response is critical in defending the body against . However, this organism has mechanisms that enable it to evade the immune system. Therefore, a more successful treatment for chronic infection would involve targeting the mechanisms of that diminish the immune response, while restoring the cell-mediated immune response.
足部癣、股癣和体癣等真菌感染的表现是全世界最常见的人类皮肤疾病。约80%患有急性皮肤癣菌病的患者对局部抗真菌治疗反应良好。然而，其余20%的患者会发展为慢性皮肤癣菌病，对抗真菌治疗具有抗性。因此，有必要更好地理解和认识对毛癣菌的多种免疫反应，因为这对于为那些患有慢性（）感染的个体制定治疗策略至关重要。因此，进行了一项全面的文献综述，以回顾和讨论之前评估人体对感染防御的研究，并了解这些真菌感染为何以及如何侵入宿主防御系统。我们的研究表明，细胞介导的免疫反应在保护身体免受（）侵害方面至关重要。然而，这种生物体具有使其能够逃避免疫系统的机制。因此，针对慢性（）感染的更成功治疗将涉及针对那些削弱免疫反应的（）机制，同时恢复细胞介导的免疫反应。
