[帕金森病中的多巴胺调节异常综合征与丘脑底核的深部脑刺激]
[Syndrome dopamine dysregulation and deep brain stimulation of the subthalamic nucleus in Parkinson's disease].
作者信息
Omarova S M, Fedorova N V, Tomskiy A A, Gamaleya A A, Bril' E V, Gubareva N N, Poddubskaya A A
机构信息
Russian Medical Academy of Continuing Postgraduate Education, Moscow, Russia.
Burdenko National Research Centre of Neurosurgery, Moscow, Russia.
出版信息
Zh Nevrol Psikhiatr Im S S Korsakova. 2017;117(12):27-32. doi: 10.17116/jnevro201711712127-32.
AIM
Dopamine dysregulation syndrome (DDS) is a complication of the dopaminergic therapy in Parkinson's disease (PD); it is manifested as a compulsive medication use and may have negative impact on patients' social, psychological, and physical functioning. An effect of deep brain stimulation in the subthalamic nucleus (DBS STN) on DDS is not fully understood. Therefore, the degree of DDS during DBS STN in PD patients was evaluated in the study.
MATERIAL AND METHODS
The main group included 15 patients with DDS symptoms in the preoperative period. The comparison group consisted of 15 patients without DDS symptoms and the control group consisted of 15 patients who did not undergo surgery.
RESULTS AND CONCLUSION
The severity of motor disturbances in the surgery groups has decreased significantly (by 45%). Motor complications during DBS STN in patients with DDS have decreased by 50%; a decrease in the reduction of doses of dopaminergic preparations was noted as well.
目的
多巴胺调节障碍综合征（DDS）是帕金森病（PD）多巴胺能治疗的一种并发症；其表现为强迫性用药，可能对患者的社交、心理和身体功能产生负面影响。丘脑底核深部脑刺激（DBS-STN）对DDS的影响尚未完全明确。因此，本研究评估了帕金森病患者在接受DBS-STN治疗期间DDS的程度。
材料与方法
主要组包括15例术前有DDS症状的患者。比较组由15例无DDS症状的患者组成，对照组由15例未接受手术的患者组成。
结果与结论
手术组运动障碍的严重程度显著降低（降低了45%）。患有DDS的患者在接受DBS-STN治疗期间运动并发症减少了50%；同时还注意到多巴胺能制剂剂量减少的幅度有所降低。
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