非亨廷顿病性舞蹈症：五件新事。
The non-Huntington disease choreas: Five new things.
作者信息
Walker Ruth H
机构信息
Department of Neurology, James J. Peters Veterans Affairs Medical Center, Bronx; and Department of Neurology, Mount Sinai School of Medicine, New York, NY.
出版信息
Neurol Clin Pract. 2016 Apr;6(2):150-156. doi: 10.1212/CPJ.0000000000000236.
PURPOSE OF REVIEW
Chorea can be due to a wide variety of causes. In this review, I provide updates on several recently identified genetic and autoimmune causes of chorea, and review evidence supporting the use of deep brain stimulation in chorea.
RECENT FINDINGS
New genes that may cause chorea include (encoding for adenylate cyclase 5) (in addition to amyotrophic lateral sclerosis and frontotemporal dementia), and those responsible for the neurodegeneration with brain iron accumulation disorders. Novel autoantibodies are increasingly being identified as associated with a variety of neurologic syndromes, including chorea, in both paraneoplastic and non-paraneoplastic settings. Deep brain stimulation can be a useful intervention in patients with chorea who do not respond to oral medications, whether due to neurodegenerative or nondegenerative causes.
SUMMARY
New causes of chorea continue to be identified. Correct diagnosis is essential for prognostication and treatment.
综述目的
舞蹈症可能由多种原因引起。在本综述中，我提供了一些近期发现的舞蹈症遗传和自身免疫病因的最新信息，并回顾了支持在舞蹈症中使用深部脑刺激的证据。
最新发现
可能导致舞蹈症的新基因包括（编码腺苷酸环化酶5）（除肌萎缩侧索硬化症和额颞叶痴呆外），以及那些与脑铁沉积障碍所致神经退行性变相关的基因。越来越多的新型自身抗体被确定与多种神经系统综合征相关，包括副肿瘤性和非副肿瘤性环境中的舞蹈症。深部脑刺激对于对口服药物无反应的舞蹈症患者可能是一种有用的干预措施，无论病因是神经退行性还是非退行性。
总结
舞蹈症的新病因不断被发现。正确诊断对于预后和治疗至关重要。
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