Department of Neurology, Temple University, Philadelphia, PA, USA.
Department of Neurology, James J. Peters Veterans Affairs Medical Center, Bronx, NY, USA; Department of Neurology, Mount Sinai School of Medicine, New York City, NY, USA.
Parkinsonism Relat Disord. 2024 May;122:106045. doi: 10.1016/j.parkreldis.2024.106045. Epub 2024 Feb 13.
Chorea is primarily due to an imbalance of basal ganglia output pathways, often due to dysfunction or degeneration of the caudate nucleus and putamen, and can be due to many causes.
We reviewed the recent literature to identify newly-recognized causes of chorea, including auto-immune, metabolic, and genetic. We also focused upon developments in mechanisms relating to underlying pathophysiology of certain genetic choreas and advances in therapeutics.
Novel autoantibodies continue to be identified as causes of chorea. Both COVID-19 infection and vaccination are reported to result rarely in chorea, although in some cases causality is not clearly established. Advances in genetic testing continue to find more causes of chorea, and to expand the phenotype of known genetic disorders. Deep brain stimulation can be successful in certain circumstances.
Our understanding of mechanisms underlying this movement disorder continues to advance, however much remains to be elucidated.
舞蹈症主要是由于基底节输出通路失衡引起的，通常是由于尾状核和壳核的功能障碍或退化引起的，也可能由多种原因引起。
我们回顾了最近的文献，以确定舞蹈症的新的可识别原因，包括自身免疫、代谢和遗传因素。我们还重点研究了与某些遗传性舞蹈症的潜在病理生理学相关的机制的进展以及治疗方法的进展。
新型自身抗体继续被确定为舞蹈症的病因。虽然在某些情况下因果关系尚不清楚，但 COVID-19 感染和疫苗接种都有罕见导致舞蹈症的报道。遗传检测的进步继续发现更多的舞蹈症病因，并扩大了已知遗传性疾病的表型。在某些情况下，深部脑刺激可以成功。
我们对这种运动障碍的潜在机制的理解仍在不断发展，但仍有许多问题需要阐明。
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